التفاصيل البيبلوغرافية
| العنوان: |
Assessing textbook outcome after single large hepatocellular carcinoma resection. |
| المؤلفون: |
Sindayigaya, Rémy1,2 (AUTHOR) remy.sindayigaya@aphp.fr, Tzedakis, Stylianos1,2 (AUTHOR), Tribillon, Ecoline3 (AUTHOR), Gavignet, Chloé1 (AUTHOR), Mazzotta, Alessandro3 (AUTHOR), Nassar, Alexandra1 (AUTHOR), Marchese, Ugo1 (AUTHOR), Soubrane, Olivier3 (AUTHOR), Fuks, David1,2 (AUTHOR) |
| المصدر: |
HPB. Sep2023, Vol. 25 Issue 9, p1093-1101. 9p. |
| مصطلحات موضوعية: |
*HEPATOCELLULAR carcinoma, *BIOMARKERS, *TEXTBOOKS, *MULTIVARIATE analysis |
| مستخلص: |
This study aimed to investigate the impact and predictors of an ideal surgical care following SLHCC resection. SLHCC patients who underwent LR in two tertiary hepatobiliary centers between 2000 and 2021 were retrieved from prospectively maintained databases. The quality of surgical care was measured by the textbook outcome (TO). Tumor burden was defined by the tumor burden score (TBS). Factors associated with TO were determined on multivariate analysis. The impact of TO on oncological outcomes was assessed using Cox regressions. Overall, 103 SLHCC patients were included. Laparoscopic approach was considered in 65 (63.1%) patients and 79 (76.7%) patients presented with moderate TBS. TO was achieved in 54 (52.4%) patients. Laparoscopic approach was independently associated with TO (OR 2.57; 95% CI 1.03–6.64; p = 0.045). Within 19 (6–38) months of median follow up, patients who achieved TO had better OS compared to non-TO patients (1-year OS: 91.7% vs. 66.9%; 5-year OS: 83.4% vs. 37.0%, p < 0.0001). On multivariate analysis, TO was independently associated with improved OS, especially in non-cirrhotic patients (HR 0.11; 95% CI 0.02–0.52, p = 0.005). TO achievement could be a relevant surrogate marker of improved oncological care following SLHCC resection in non-cirrhotic patients. [Display omitted] [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
