التفاصيل البيبلوغرافية
| العنوان: |
Cefepime Versus Piperacillin-Tazobactam for the Treatment of Intra-Abdominal Infections Secondary to Potential AmpC Beta-Lactamase-Producing Organisms. |
| المؤلفون: |
Gamble, Kelly C., Rose, Dusten T., Chang, Stephanie Y., Hodge, Emily K., Jaso, Theresa C., Trust, Marc D., Daley, Mitchell J. |
| المصدر: |
Hospital Pharmacy; Dec2023, Vol. 58 Issue 6, p575-583, 9p |
| مصطلحات موضوعية: |
RESEARCH, LENGTH of stay in hospitals, INTRAVENOUS therapy, RETROSPECTIVE studies, ACQUISITION of data, ANTI-infective agents, INTRA-abdominal infections, CEFEPIME, PENICILLIN, DISEASE relapse, HOSPITAL mortality, CLOSTRIDIUM diseases, BETA lactamases, MEDICAL records, SURGICAL site infections, DESCRIPTIVE statistics, GRAM-negative bacterial diseases, LONGITUDINAL method, CHEMICAL inhibitors |
| مستخلص: |
Background: Recent studies have established cefepime as an effective treatment option for AmpC beta-lactamase (AmpC) Enterobacterales; however, the efficacy of beta-lactam/beta-lactamase inhibitors is unclear. Objective: The objective of this study was to determine if piperacillintazobactamis an appropriate alternative to cefepime for the treatment of intra-abdominal infections (IAIs) secondary to AmpC-producing organisms. Methods: This multicenter, retrospective cohort study was conducted in hospitalized adults with an IAI caused by an AmpC-producing organism and received either cefepime or piperacillin-tazobactam for definitive treatment after a source control procedure. The primary outcome was a composite of surgical site infections, recurrent IAIs, or in-hospital mortality. Secondary outcomes included the individual components of the composite outcome, hospital length of stay (LOS), microbiologic failure, study antibiotic duration, time to clinical resolution, and incidence of Clostridioides difficile infection (CDI). Results: This study included 119 patients. There was no difference in the primary outcome between the cefepime and piperacillin-tazobactam groups (35% vs 27%, P = 0.14). Microbiological failure was the only secondary outcome with an observed difference between groups (17% vs 0%, P = 0.01): hospital LOS (15 vs 13 days, P = 0.09), days of therapy (7 vs 7 days, P = 0.87), time to clinical resolution (7 vs 4 days, P = 0.30), and CDI (1% vs 2%, P = 0.58) were all similar. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
