التفاصيل البيبلوغرافية
| العنوان: |
Aromatase Overexpression: Effect of Tissue Estrogen on Phenotypic and Biochemical Changes in Aromatase Transgenic Mice. |
| المؤلفون: |
Li, Jonathan J., Li, Sara A., Llombart-Bosch, Antonio, Tekmal, Rajeshwar Rao, Kirma, Nameer, Mandava, Usha, Luthra, Roopa |
| المصدر: |
Hormonal Carcinogenesis IV; 2005, p130-140, 11p |
| مستخلص: |
Studies summarized herein demonstrate that overexpression of ARO leads to in increased tissue estrogenic activity, induction of MG hyperplastic and dysplastic lesions, gynecomastia, and testicular cancer in male ARO transgenic mice. The preneoplastic lesions induced due to increased tissue estrogenic activity are susceptible to carcinogens. The ARO overexpression-induced MG changes were inhibited with very low letrazole doses, an ARO inhibitor without any effect on normal physiology. The potential clinical importance of this intracrine growth support may provide future clinical and laboratory investigations. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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