دورية أكاديمية
Isolation, evaluation of bioactivity and structure determination of amethinol A, a prototypic amethane diterpene from Isodon amethystoides bearing a six/five/seven-membered carbon-ring system
| العنوان: | Isolation, evaluation of bioactivity and structure determination of amethinol A, a prototypic amethane diterpene from Isodon amethystoides bearing a six/five/seven-membered carbon-ring system |
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| المؤلفون: | Zhao, Chen-Liang, Sarwar, Md. Shahid, Ye, Jiang-Hai, Ku, Chuen Fai, Li, Wan-Fe, Luo, Guo-Yong, Zhang, Jing-Jie, Xu, Jun, Huang, Zhao-Feng, Tsang, Sui Wai, Pan, Lu-Tan, Zhang, Hong-Jie |
| المصدر: | HKBU Staff Publication |
| بيانات النشر: | HKBU Institutional Repository |
| سنة النشر: | 2018 |
| المجموعة: | Hong Kong Baptist University: HKBU Institutional Repository |
| مصطلحات موضوعية: | Isodon amethystoides, Lamiaceae, amethane diterpene, amethinol A, RORγt antagonist, crystal structure, natural product, biosynthetic pathway, School of Chinese Medicine, Medicine and Health Sciences |
| الوصف: | We report the isolation of a novel diterpene, designated as `amethane', from Isodon amethystoides (Lamiaceae). The diterpene [amethinol A; systematic name: (4aR,4bR,7R,10aS)-4b,7-dihydroxy-7-isopropyl-1,1-dimethyl-9-oxododecahydrobenzo[a]azulene-4a(2H)-carboxylic acid], possesses a unique skeleton containing a six/five/seven-membered tricyclic system. Intermolecular O—HO close contacts were found to the carboxyl, carbonyl and hydroxy groups, connecting molecules into a two-dimensional structure. A possible biosynthetic pathway has been proposed. In addition, the compound was evaluated for its biological activities against different disease targets, and was found to significantly attenuate RORγt-dependent autoimmune responses. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://repository.hkbu.edu.hk/hkbu_staff_publication/6888Test; https://repository.hkbu.edu.hk/cgi/viewcontent.cgi?article=7912&context=hkbu_staff_publicationTest |
| الإتاحة: | https://repository.hkbu.edu.hk/hkbu_staff_publication/6888Test https://repository.hkbu.edu.hk/cgi/viewcontent.cgi?article=7912&context=hkbu_staff_publicationTest |
| رقم الانضمام: | edsbas.261BC185 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |