التفاصيل البيبلوغرافية
| العنوان: |
Kidney tubule health scores and their associations with incident CKD in women living with HIV |
| المؤلفون: |
Ascher, Simon B., Scherzer, Rebecca, Estrella, Michelle M., Muiru, Anthony N., Jotwani, Vasantha K., Grunfeld, Carl, Shigenaga, Judy, Spaulding, Kimberly A., Ng, Derek K., Gustafson, Deborah, Spence, Amanda B., Sharma, Anjali, Cohen, Mardge H., Parikh, Chirag R., Ix, Joachim H., Shlipak, Michael G. |
| المصدر: |
HIV Med |
| سنة النشر: |
2021 |
| مصطلحات موضوعية: |
Article, demo, hisphilso |
| الوصف: |
OBJECTIVES: Individual kidney tubule biomarkers are associated with CKD risk in persons living with HIV (PLWH). Whether a combination of kidney biomarkers can be integrated into informative summary scores for PLWH is unknown. METHODS: We measured 8 urine biomarkers of kidney tubule health at 2 visits over a 3-year period in 647 women living with HIV in the Women’s Interagency Health Study. We integrated biomarkers into factor scores using exploratory factor analysis. We evaluated associations between CKD risk factors and factor scores, and used generalized estimating equations to determine associations between factor scores and risk of incident CKD. RESULTS: Factor analysis identified 2 unique factor scores: a tubule reabsorption score comprising α-1-microglobulin, beta-2-microglobulin, and trefoil factor-3 and a tubule injury score comprising interleukin-18 and kidney injury molecule-1. We modeled the 2 factor scores in combination with urine epidermal growth factor (EGF) and urine albumin. Predominantly HIV-related CKD risk factors were independently associated with worsening tubule reabsorption scores and tubule injury scores. During a median follow-up of 7 years, 9.7% (63/647) developed CKD. In multivariable time-updated models that adjusted for other factor scores and biomarkers simultaneously, higher tubule reabsorption scores (RR=1.27, 95% CI: 1.01, 1.59 per 1-SD higher time-updated score), higher tubule injury scores (RR=1.36, 95% CI: 1.05, 1.76), lower urine EGF (RR=0.75, 95% CI: 0.64, 0.87), and higher urine albumin (RR=1.20, 95% CI: 1.02, 1.40) were jointly associated with risk of incident CKD. CONCLUSIONS: We identified 2 novel and distinct dimensions of kidney tubule health that appear to quantify informative metrics of CKD risk in PLWH. |
| نوع الوثيقة: |
text |
| اللغة: |
English |
| العلاقة: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803539Test/ |
| الإتاحة: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803539Test/ |
| حقوق: |
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| رقم الانضمام: |
edsbas.267E8A2E |
| قاعدة البيانات: |
BASE |
