التفاصيل البيبلوغرافية
| العنوان: |
Influence of splenectomy in patients with liver cirrhosis and hypersplenism. |
| المؤلفون: |
Nomura, Yoriko, Kage, Masayoshi, Ogata, Toshirou, Kondou, Reiichirou, Kinoshita, Hisafumi, Ohshima, Kouichi, Yano, Hirohisa |
| المصدر: |
Hepatology Research; Oct2014, Vol. 44 Issue 10, pE100-E109, 10p |
| مصطلحات موضوعية: |
CIRRHOSIS of the liver, SPLENECTOMY, HYPERSPLENISM, IMMUNOHISTOCHEMISTRY, THROMBOCYTOPENIA, ANTINEOPLASTIC agents, LYMPHOCYTES |
| مستخلص: |
Aim Splenectomy improves hypersplenic thrombocytopenia in cirrhotic patients with hypersplenism. However, the long-term influence of splenectomy has not been clarified. We examined whether splenectomy improved liver fibrosis and caused immunological changes. Methods We collected liver and spleen specimens and peripheral blood ( PB) from 26 patients with hepatitis C virus-related liver cirrhosis. An immunohistochemical examination of CD4, CD8, forkhead box P3, granzyme B and transforming growth factor-β1, and Masson-trichrome stain were performed in spleen and liver tissues and in seven cases of follow-up liver biopsy sections obtained after splenectomy. We obtained PB before and at various intervals after splenectomy. We also examined the ratio of CD4+ and CD8+ lymphocytes in PB using flow cytometry. Results We observed improvements in liver fibrosis in four biopsy specimens obtained after splenectomy, in which fibrotic areas significantly decreased from 19.5% to 8.2% ( P < 0.05). Increases were also observed in the ratio of CD8+ cells in PB after splenectomy, which resulted in a significant decrease in the CD4+/ CD8+ ratio ( P < 0.001). The carcinogenic rate in patients with a CD4+ : CD8+ ratio that decreased by more than 0.5 at 1 month after splenectomy was significantly lower than that in patients with a ratio that decreased by less than 0.5 ( P < 0.05). Conclusion Splenectomy may improve liver fibrosis and cause beneficial immunological changes in cirrhotic patients with hepatitis. Improvements in antitumor mechanisms can be also expected. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
