Response to crizotinib in a patient with MET‐ amplified hepatocellular carcinoma
| العنوان: | Response to crizotinib in a patient with MET‐ amplified hepatocellular carcinoma |
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| المؤلفون: | Wenjing Wang, Xianwei Yang, Chun-Feng Xie, Mian Xu, Qing-Lian Chen, Cheng-Ming Xiong, Haijun Huang, Chong Zhong, Kun-Liang Feng, Tengjiao Lin |
| المصدر: | Hepatology Research. 51:1164-1169 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Hepatology, Crizotinib, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Met amplification, Tissue sample, Drug resistance, medicine.disease, digestive system diseases, Targeted therapy, Clinical trial, 03 medical and health sciences, 0302 clinical medicine, Infectious Diseases, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Internal medicine, Biopsy, medicine, 030211 gastroenterology & hepatology, business, medicine.drug |
| الوصف: | Aims Molecular profiling of hepatocellular carcinoma (HCC) has helped identify actionable genomic alterations that could guide therapeutic decision-making and clinical trial enrollment. However, in clinical practice, next-generation sequencing (NGS) is not extensively used in routine clinical care to identify patients with HCC who are likely to benefit from genome-directed targeted therapies. Methods Here, we describe the case of a 66-year-old man with advanced HCC. After rapid progression on transarterial chemoembolization, the tissue sample obtained from biopsy was subjected to NGS to verify whether precision therapy was an option. Results Our analysis revealed high MET amplification. The patient received crizotinib (250 mg, bid) and showed a remarkable response. Conclusions Our case report suggests NGS could help identify patients with high MET amplification in HCC who were likely to benefit from MET inhibitors; moreover, this requires further investigation in clinical trials. |
| تدمد: | 1872-034X 1386-6346 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::02f22f8438ba8a1b390f026e266a354bTest https://doi.org/10.1111/hepr.13664Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........02f22f8438ba8a1b390f026e266a354b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1872034X 13866346 |
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