DNA hypermethylation at the D17S5 locus and reducedHIC-1mRNA expression are associated with hepatocarcinogenesis
| العنوان: | DNA hypermethylation at the D17S5 locus and reducedHIC-1mRNA expression are associated with hepatocarcinogenesis |
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| المؤلفون: | Lin Sun, Saori Ushijima, Hitoshi Tsuda, Al Min Hui, Michiie Sakamoto, Setsuo Hirohashi, Yae Kanai |
| المصدر: | Hepatology. 29:703-709 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Adult, Male, Carcinoma, Hepatocellular, Cirrhosis, Kruppel-Like Transcription Factors, Loss of Heterozygosity, Locus (genetics), Biology, Methylation, Loss of heterozygosity, medicine, Humans, RNA, Messenger, Gene, Aged, Hepatology, Reverse Transcriptase Polymerase Chain Reaction, Liver Neoplasms, Chromosome Mapping, DNA, Middle Aged, HCCS, medicine.disease, digestive system diseases, Liver, Hepatocellular carcinoma, DNA methylation, Cancer research, Female, Transcription Factors |
| الوصف: | To examine the significance of aberrant DNA methylation in hepatocarcinogenesis, the DNA methylation status at the D17S5 locus and mRNA expression of a candidate tumor suppressor gene, HIC-1 (hypermethylated-in-cancer), which was identified at the D17S5 locus, in primary hepatocellular carcinomas (HCCs) and their corresponding noncancerous liver tissues were assessed. DNA hypermethylation at the D17S5 locus was detected in 44% of the noncancerous liver tissues showing chronic hepatitis or cirrhosis, which are widely considered to be precancerous conditions, but was not observed in noncancerous liver tissues showing no remarkable histological findings. The incidence of DNA hypermethylation at this locus was significantly higher in HCCs (90%) than noncancerous liver tissues (P |
| تدمد: | 1527-3350 0270-9139 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d60ac619591b59881cc318e3612563bTest https://doi.org/10.1002/hep.510290338Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....8d60ac619591b59881cc318e3612563b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15273350 02709139 |
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