A developmentally prometastatic niche to hepatoblastoma in neonatal liver mediated by the Cxcl1/Cxcr2 axis
| العنوان: | A developmentally prometastatic niche to hepatoblastoma in neonatal liver mediated by the Cxcl1/Cxcr2 axis |
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| المؤلفون: | Li Fan, Qingfei Pan, Wentao Yang, Selene C. Koo, Cheng Tian, Liyuan Li, Meifen Lu, Anthony Brown, Bensheng Ju, John Easton, Sarangarajan Ranganathan, Soona Shin, Alexander Bondoc, Jun J. Yang, Jiyang Yu, Liqin Zhu |
| المصدر: | Hepatology. 76:1275-1290 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Hepatoblastoma, Mice, Hepatology, Chemokine CXCL1, Liver Neoplasms, Animals, RNA, Receptors, Interleukin-8B |
| الوصف: | Hepatoblastoma (HB) is the most common pediatric liver cancer. Its predominant occurrence in very young children led us to investigate whether the neonatal liver provides a protumorigenic niche to HB development.HB development was compared between orthotopic transplantation models established in postnatal day 5 (P5) and 60 (P60) mice (P5We found that various HB cell lines including HepG2 cells were consistently and considerably more tumorigenic and metastatic in the P5 |
| تدمد: | 1527-3350 0270-9139 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a70a83c74b35257b4076ef7a2de0f5aTest https://doi.org/10.1002/hep.32412Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4a70a83c74b35257b4076ef7a2de0f5a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15273350 02709139 |
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