Bronchoalveolar lavage-based COVID-19 testing in patients with cancer
| العنوان: | Bronchoalveolar lavage-based COVID-19 testing in patients with cancer |
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| المؤلفون: | Mary Beth Graham, Bicky Thapa, Muhammad Bilal Abid, Mehdi Hamadani, Saurabh Chhabra, Blake W. Buchan, Anita D'Souza, Ben George, Sameem Abedin |
| المصدر: | Hematology/Oncology and Stem Cell Therapy, Vol 14, Iss 1, Pp 65-70 (2021) Hematology/Oncology and Stem Cell Therapy |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Bronchoalveolar lavage, medicine.medical_specialty, Coronavirus Disease 2019 (COVID-19), Brief Communication, lcsh:RC254-282, 03 medical and health sciences, 0302 clinical medicine, COVID-19 Testing, Bronchoscopy, Hematological malignancy, Internal medicine, Neoplasms, medicine, Infection control, Humans, Corticosteroids, Sampling (medicine), Immunocompromised, Aged, Retrospective Studies, Cancer, Aged, 80 and over, medicine.diagnostic_test, business.industry, SARS-CoV-2, lcsh:RC633-647.5, COVID-19, Retrospective cohort study, Hematology, General Medicine, lcsh:Diseases of the blood and blood-forming organs, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Clinical trial, Oncology, 030220 oncology & carcinogenesis, Airway, business, 030215 immunology |
| الوصف: | Objective/Background A few case reports in the setting of coronavirus disease 2019 (COVID-19) and multiplex polymerase chain reaction (PCR)-based assays for common respiratory pathogens have shown a higher yield of bronchoalveolar lavage (BAL) samples than upper airway specimens in immunocompromised patients. Methods A retrospective study was conducted reviewing patients diagnosed with COVID-19 at the Medical College of Wisconsin (Milwaukee, WI, USA) between March 13, 2020 and June 11, 2020. All patients tested positive for SARS-CoV-2 via real-time reverse transcriptase PCR (RT-PCR), through a nasopharyngeal or a bronchoscopy specimen. Results During the study period, 53 bronchoscopy procedures were performed at the institution, of which five patients tested positive for COVID-19. Of the five patients, three underwent BAL testing based on high clinical suspicion for COVID-19 after the nasopharyngeal (NP) swab(s) was negative. All three patients had underlying cancers and had lymphopenia for a considerable duration prior to being diagnosed with COVID-19. Two patients had better outcomes that could be attributed to earlier BAL specimen testing resulting in timely medical intervention. Conclusion This study underscores the need for early lower respiratory tract sampling, whenever possible, in patients with cancer and prolonged lymphopenia. High clinical suspicion ought to supersede false-negative NP reverse transcriptase–PCR as early bronchoscopic evaluation in cancer patients, who are either receiving active treatment or are immunosuppressed, can allow timely institution of efficacious treatment, enrollment into clinical trials, as well as effective infection control. In the apt clinical setting in patients with cancer, presumptive treatment may also be considered to minimize exposure to healthcare providers and proceduralists. |
| اللغة: | English |
| تدمد: | 1658-3876 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe6d31acbdb39fc32116f8f8f9d72f5Test http://www.sciencedirect.com/science/article/pii/S1658387620301497Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9fe6d31acbdb39fc32116f8f8f9d72f5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16583876 |
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