التفاصيل البيبلوغرافية
| العنوان: |
Treatment of gastric marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue with rituximab, cyclophosphamide, vincristine and prednisone. |
| المؤلفون: |
Aguiar‐Bujanda, David, Llorca‐Mártinez, Ignacio, Rivero‐Vera, José C., Blanco‐Sánchez, María J., Jiménez‐Gallego, Pedro, Mori‐De Santiago, Marta, Limeres‐Gonzalez, Miguel A., Cabrera‐Marrero, José C., Hernández‐Sosa, María, Galván‐Ruíz, Saray, Hernández‐Sarmiento, Samuel, Saura Grau, Salvador, Bohn‐Sarmiento, Uriel |
| المصدر: |
Hematological Oncology; Sep2014, Vol. 32 Issue 3, p139-144, 6p |
| مستخلص: |
There is no standard treatment for patients with gastric marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) who are resistant to, or ineligible for, anti- Helicobacter pylori (anti-HP) therapy. In this study, we investigated the activity of the rituximab, cyclophosphamide, vincristine and prednisone (R-CVP) regimen in patients with gastric MALT lymphoma. Patients were included provided they had untreated gastric MALT lymphoma (except for anti-HP therapy) and were resistant to, or ineligible for, anti-HP therapy. Treatment plan consisted of six to eight 21-day cycles of the R-CVP chemotherapy regimen. Toxicity, response, relapse and survival were evaluated. Twenty patients (12 women and 8 men) were included in the analyses with median age of 59 years. Thirteen patients (65%) had stage I tumours, and seven patients (35%) had stages II-IV tumours. The overall response rate was 100%, with 19 (95%) complete responses and one (5%) partial response. Regimen toxicity was mild and mainly hematological, and no cases of gastric bleeding or perforation occurred. After a median follow-up of 56.3 months, three patients had relapsed, and 19 patients remained alive (specific lymphoma survival 100%), of whom 17 had no evidence of disease. In our experience, the R-CVP regimen is a well-tolerated and effective treatment for patients with gastric MALT lymphoma who are resistant to, or ineligible for, anti-HP therapy. Copyright © 2013 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
