دورية أكاديمية
Prophylactic cranial irradiation-related lymphopenia affects survival in patients with limited-stage small cell lung cancer
| العنوان: | Prophylactic cranial irradiation-related lymphopenia affects survival in patients with limited-stage small cell lung cancer |
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| المؤلفون: | Xinyu Fan, Linlin Yang, Wenru Qin, Bing Zou, Bingjie Fan, Shijiang Wang, Linlin Wang |
| المصدر: | Heliyon, Vol 9, Iss 6, Pp e16483- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Limited-stage small-cell lung cancer (LS-SCLC), Overall survival (OS), Lymphopenia, Prophylactic cranial irradiation (PCI), Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Background: The study aimed to identify the relations of the absolute lymphocyte count (ALC) nadir during prophylactic cranial irradiation (PCI) and patient outcomes in limited-stage small cell lung cancer (LS-SCLC). Methods: We analyzed 268 L S-SCLC patients who underwent PCI from 2012 to 2019. ALC values were collected prior, during, and 3 months post PCI. Kaplan–Meier and Cox regression analyses were performed to assess the relation of ALC to patient prognosis. Two nomograms were developed on the basis of clinical variables for survival prediction. Results: Compared with the ALC before PCI (1.13 × 109 cells/L), the ALC nadir during PCI was significantly reduced by 0.68 × 109 cells/L (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2405844023036903Test; https://doaj.org/toc/2405-8440Test |
| DOI: | 10.1016/j.heliyon.2023.e16483 |
| الوصول الحر: | https://doaj.org/article/07bf78c142524bcf994e12032966bfbfTest |
| رقم الانضمام: | edsdoj.07bf78c142524bcf994e12032966bfbf |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2023.e16483 |