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Metabolomics comparison of metabolites and functional pathways in the SH-SY5Y cell model of Parkinson's disease under PEMF exposure

التفاصيل البيبلوغرافية
العنوان: Metabolomics comparison of metabolites and functional pathways in the SH-SY5Y cell model of Parkinson's disease under PEMF exposure
المؤلفون: Li-na Zhu, Deng Chen, Chengqi He
المصدر: Heliyon, Vol 10, Iss 4, Pp e26540- (2024)
بيانات النشر: Elsevier, 2024.
سنة النشر: 2024
المجموعة: LCC:Science (General)
LCC:Social sciences (General)
مصطلحات موضوعية: PEMF, Metabolomics, PD, SH-SY5Y, Cell model, Science (General), Q1-390, Social sciences (General), H1-99
الوصف: Objective: PEMF is an emerging technique in the treatment of Parkinson's disease (PD) due to its potential improvement of movement speed. The aim of this study was to investigate the metabolic profiles of pulsed electromagnetic fields (PEMFs) in an SH-SY5Y cell model of PD. Methods: The SH-SY5Y cell model of PD was induced by 1-methyl-4-phenylpyridinium (MPP+). Liquid chromatography mass spectrometry (LC‒MS)-based untargeted metabolomics was performed to examine changes in the PD cell model with or without PEMF exposure. We conducted KEGG pathway enrichment analysis to explore the potentially related pathways of the differentially expressed metabolites. Results: A total of 275 metabolites were annotated, and 27 significantly different metabolites were found between the PEMF treatment and control groups (VIP >1, P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2405-8440
العلاقة: http://www.sciencedirect.com/science/article/pii/S2405844024025714Test; https://doaj.org/toc/2405-8440Test
DOI: 10.1016/j.heliyon.2024.e26540
الوصول الحر: https://doaj.org/article/3ade1adb09f84fae9aadd7263c2a28e3Test
رقم الانضمام: edsdoj.3ade1adb09f84fae9aadd7263c2a28e3
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:24058440
DOI:10.1016/j.heliyon.2024.e26540