دورية أكاديمية
Conditional reprogrammed human limbal epithelial cell model for anti-SARS-CoV-2 drug screening
| العنوان: | Conditional reprogrammed human limbal epithelial cell model for anti-SARS-CoV-2 drug screening |
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| المؤلفون: | Yu Xiao, Ling Wang, Shi-xu Li, Shi-song Fang, Fan Luo, Shu-liang Chen, Xuan Zou, Lin Ye, Wei Hou |
| المصدر: | Heliyon, Vol 10, Iss 9, Pp e30044- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | COVID-19, Limbal, Cell model, Drug screening, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | To minimize the global pandemic COVID-19 spread, understanding the possible transmission routes of SARS-CoV-2 and discovery of novel antiviral drugs are necessary. We describe here that the virus can infect ocular surface limbal epithelial, but not other regions. Limbal supports wild type and mutant SARS-CoV-2 entry and replication depending on ACE2, TMPRSS2 and possibly other receptors, resulting in slight CPE and arising IL-6 secretion, which symbolizes conjunctivitis in clinical symptoms. With this limbal model, we have screened two natural product libraries and discovered several unreported drugs. Our data reveal important commonalities between COVID-19 and ocular infection with SARS-CoV-2, and establish an ideal cell model for drug screening and mechanism research. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 91770254 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2405844024060754Test; https://doaj.org/toc/2405-8440Test |
| DOI: | 10.1016/j.heliyon.2024.e30044 |
| الوصول الحر: | https://doaj.org/article/ba05cd61a8eb493f9177025402593bbbTest |
| رقم الانضمام: | edsdoj.ba05cd61a8eb493f9177025402593bbb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 91770254 |
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| DOI: | 10.1016/j.heliyon.2024.e30044 |