β-Blocker pharmacogenetics in heart failure
| العنوان: | β-Blocker pharmacogenetics in heart failure |
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| المؤلفون: | Julie A. Johnson, Steven G. Terra |
| المصدر: | Heart Failure Reviews. 15:187-196 |
| بيانات النشر: | Springer Science and Business Media LLC, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | medicine.medical_specialty, Adrenergic beta-Antagonists, Adrenergic, Article, Adrenergic beta-2 Receptor Antagonists, Internal medicine, medicine, Humans, Metoprolol, Heart Failure, Polymorphism, Genetic, business.industry, medicine.disease, Adrenergic beta-1 Receptor Antagonists, Alpha-1A adrenergic receptor, Tolerability, Pharmacogenetics, Heart failure, Anesthesia, Cardiology, Receptors, Adrenergic, beta-2, Receptors, Adrenergic, beta-1, Cardiology and Cardiovascular Medicine, business, medicine.drug |
| الوصف: | Beta-blockers (metoprolol, bisoprolol, and carvedilol) are a cornerstone of heart failure (HF) treatment. However, it is well recognized that responses to a beta-blocker are variable among patients with HF. Numerous studies now suggest that genetic polymorphisms may contribute to variability in responses to a beta-blocker, including left ventricular ejection fraction improvement, survival, and hospitalization due to HF exacerbation. This review summarizes the pharmacogenetic data for beta-blockers in patients with HF and discusses the potential implications of beta-blocker pharmacogenetics for HF patients. |
| تدمد: | 1573-7322 1382-4147 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5319128e92096b95c0ad71e9e984f707Test https://doi.org/10.1007/s10741-008-9094-xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5319128e92096b95c0ad71e9e984f707 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15737322 13824147 |
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