التفاصيل البيبلوغرافية
| العنوان: |
Leptin, leptin gene and leptin receptor gene polymorphism in heart failure with preserved ejection fraction. |
| المؤلفون: |
Abd El-Aziz, Tarek, Mohamed, Randa, Mohamed, Rasha, Pasha, Heba |
| المصدر: |
Heart & Vessels; May2012, Vol. 27 Issue 3, p271-279, 9p |
| مصطلحات موضوعية: |
LEPTIN genetics, LEPTIN receptors, GENETIC polymorphisms, HEART failure, OBESITY, CORONARY disease, ISCHEMIA |
| مستخلص: |
Heart failure with a normal ejection fraction (HFNEF) is common in obesity and coronary artery disease (CAD). Both ischemia and reperfusion induce leptin (LEP) and leptin receptor (LEPR) gene expression. We aimed to investigate the possible associations of serum leptin, leptin gene and leptin receptor gene polymorphism with HFNEF in patients with CAD. 100 Egyptian CAD patients with HFNEF and 100 healthy subjects (the control group) were genotyped for LEP and LEPR polymorphism. Leptin levels were measured. Serum leptin levels were significantly increased in patients compared to the control group. There was a significant increase in the leptin gene (AA genotype) and the leptin receptor gene (RR genotype) in HFNEF patients compared to the control group. Leptin levels, leptin gene (AA genotype) and LEPR (RR genotype) were more associated with NYHA III than with NYHA I and II. We thus concluded that HFNEF is associated with increased serum leptin levels, and the LEP AA genotype or LEPR RR genotype carries at least a threefold increased risk of developing HFNEF. [ABSTRACT FROM AUTHOR] |
|
Copyright of Heart & Vessels is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
