التفاصيل البيبلوغرافية
| العنوان: |
Characteristics and Outcomes of Stem Cell Transplant Patients during the COVID-19 Era: A Systematic Review and Meta-Analysis. |
| المؤلفون: |
Kamal, Mona, Baudo, Massimo, Joseph, Jacinth, Geng, Yimin, Mohamed, Omnia, Rahouma, Mohamed, Greenbaum, Uri |
| المصدر: |
Healthcare (2227-9032); Mar2024, Vol. 12 Issue 5, p530, 14p |
| مصطلحات موضوعية: |
STEROID drugs, HEMATOPOIETIC stem cell transplantation, HYDROXYCHLOROQUINE, ANTIBIOTICS, TREATMENT effectiveness, META-analysis, SYSTEMATIC reviews, ANTIVIRAL agents, MEDLINE, MEDICAL databases, CONFIDENCE intervals, ONLINE information services, COVID-19 pandemic, IMMUNOSUPPRESSION, HEALTH care teams, IMMUNOCOMPETENCE |
| مستخلص: |
This systematic review and meta-analysis aims to identify the outcomes of stem cell transplant (SCT) patients during the COVID-19 era. Pooled event rates (PER) were calculated, and meta-regression was performed. A random effects model was utilized. In total, 36 eligible studies were included out of 290. The PER of COVID-19-related deaths and COVID-19-related hospital admissions were 21.1% and 55.2%, respectively. The PER of the use of hydroxychloroquine was 53.27%, of the receipt of immunosuppression it was 39.4%, and of the use of antivirals, antibiotics, and steroids it was 71.61%, 37.94%, and 18.46%, respectively. The PER of the time elapsed until COVID-19 infection after SCT of more than 6 months was 85.3%. The PER of fever, respiratory symptoms, and gastrointestinal symptoms were 70.9, 76.1, and 19.3%, respectively. The PER of acute and chronic GvHD were 40.2% and 60.9%, respectively. SCT patients are at a higher risk of severe COVID-19 infection and mortality. The use of dexamethasone improves the survival of hospitalized SCT patients with moderate to severe COVID-19 requiring supplemental oxygen or ventilation. The SCT patient group is a heterogeneous group with varying characteristics. The quality of reporting on these patients when infected with COVID-19 is not uniform and further prospective or registry studies are needed to better guide clinical care in this unique setting. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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