Effect of mango seed kernel extract on the adipogenesis in 3T3-L1 adipocytes and in rats fed a high fat diet
| العنوان: | Effect of mango seed kernel extract on the adipogenesis in 3T3-L1 adipocytes and in rats fed a high fat diet |
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| المؤلفون: | Akiko Kojima-Yuasa, Isao Matsui-Yuasa, Maiko Fukuda-Shimizu, Hiroshi Munakata, Mai Kobayashi, Yoshinobu Mandai, Masaki Tabuchi |
| المصدر: | Health. :9-15 |
| بيانات النشر: | Scientific Research Publishing, Inc., 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | digestive, oral, and skin physiology, food and beverages, 3T3-L1, Biology, medicine.disease, Obesity, chemistry.chemical_compound, Nutraceutical, chemistry, In vivo, Adipogenesis, medicine, Glycerol, Mangifera, Food science, Steatohepatitis |
| الوصف: | Mangoes (Mangifera indica L.) are one of the most important tropical foods. The seed is one of the main by-products of mango processing. Therefore, it is important to find an economically viable use for this waste (e.g., as a food additive or supplement with high nutraceutical value). We investigated the anti-obesity effects of mango seed kernel extract with hot water (MSKE-W) in 3T3-L1 adipocytes and in a high fat diet (HFD)-induced obesity rat model. MSKE-W caused a significant decrease in the activity of glycerol 2-phosphate dehydrogenase in 3T3-L1 adipocytes without eliciting cell cytotoxicity and inhibited cellular lipid accumulation through down-regulation of transcription factors such as PPARγ and C/EBPα. In the animal model, rats fed an HFD containing 1% MSKE-W gained less weight than rats fed an HFD alone. The visceral fat mass in rats fed an HFD containing 1% MSKE-W tended to be lower than that in rats fed an HFD alone. Furthermore, histological examination of rat livers from an HFD showed steatohepatitis. However, rats on an HFD containning 1% MSKE-W showed no histopathological changes in liver tissue. Our results indicate that MSKE-W influences anti-obesity effects, both in vitro and in vivo, and suggest that MSKE-W provides a novel preventive potential against obesity. |
| تدمد: | 1949-5005 1949-4998 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::20cffa7e254c419dfdff721cb419c4b1Test https://doi.org/10.4236/health.2013.58a3002Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........20cffa7e254c419dfdff721cb419c4b1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19495005 19494998 |
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