التفاصيل البيبلوغرافية
| العنوان: |
Serum decoy receptor 3 level: a predictive marker for nodal metastasis and survival among oral cavity cancer patients |
| المؤلفون: |
Kuo Wei Chang, Shyun Yeu Liu, Yu Ping Chen, En Hao Yu, Shu Chun Lin, Hsi Feng Tu, Chung Ji Liu |
| المصدر: |
Headneck. 33(3) |
| سنة النشر: |
2010 |
| مصطلحات موضوعية: |
Oncology, Adult, Male, medicine.medical_specialty, Pathology, Kaplan-Meier Estimate, medicine.disease_cause, Risk Assessment, Disease-Free Survival, Metastasis, Cohort Studies, Predictive Value of Tests, Internal medicine, medicine, Carcinoma, Biomarkers, Tumor, Confidence Intervals, Odds Ratio, Humans, Neoplasm Invasiveness, Survival analysis, Aged, Neoplasm Staging, Proportional Hazards Models, Predictive marker, business.industry, Biopsy, Needle, Receptors, Tumor Necrosis Factor, Member 6b, Cancer, Middle Aged, medicine.disease, Prognosis, Primary tumor, Immunohistochemistry, Survival Analysis, Logistic Models, Otorhinolaryngology, Lymphatic Metastasis, Carcinoma, Squamous Cell, Female, Mouth Neoplasms, Decoy receptor 3, business, Carcinogenesis |
| الوصف: |
Background. Validating markers for prediction of nodal metastasis could be beneficial in treatment of oral cavity cancer. Decoy receptor 3 (DcR3), locus on 20q13, functions as a death decoy inhibiting apoptosis mediated by the tumor necrosis factor receptor (TNFR) family. Methods. This study analyzed the serum level of DcR3 in relationship to the clinical parameters of oral cavity cancer patients together with detection of DcR3 genomic copy number in primary and recurrent tumors. Results. Elevated serum DcR3 was associated with nodal metastasis and worse prognosis. Gain of DcR3 copy number was detected in 17% of primary tumor tissue but not found in healthy areca chewers. Tissue from recurrent tumors showed more frequent DcR3 copy number alteration (48%) than the paired primary tumor tissue. Conclusions. Serum DcR3 level is a predictor for the nodal metastasis and survival among oral cavity cancer patients and the DcR3 copy number alteration could underlie oral carcinogenesis progression. © 2010 Wiley Periodicals, Inc. Head Neck, 2010 |
| تدمد: |
1097-0347 |
| الوصول الحر: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ccd8126a4f3c2e25aa26ad0b72d271Test
https://pubmed.ncbi.nlm.nih.gov/20645287Test |
| حقوق: |
CLOSED |
| رقم الانضمام: |
edsair.doi.dedup.....a0ccd8126a4f3c2e25aa26ad0b72d271 |
| قاعدة البيانات: |
OpenAIRE |
