التفاصيل البيبلوغرافية
| العنوان: |
Safety, tolerability, pharmacokinetics and pharmacodynamics of a single dose of marstacimab in Chinese participants with severe haemophilia. |
| المؤلفون: |
Sun, Xiaohong, Liu, Wei, Luo, Binyu, Ma, Dongwei, Kalluru, Hindu, Zhou, Yangmei, Li, Jin, Peng, Ao, Liu, Yuwang, Tong, Xin, Sun, Lei, Teeter, John, Raje, Sangeeta, Yang, Renchi |
| المصدر: |
Haemophilia; Jul2023, Vol. 29 Issue 4, p1155-1159, 5p, 1 Chart, 1 Graph |
| مصطلحات موضوعية: |
CHINESE people, HEMOPHILIA, PHARMACOKINETICS, PHARMACODYNAMICS, THROMBIN, INTRAVENOUS immunoglobulins |
| مستخلص: |
Blood samples for PK and PD analyses were taken pre-dose and 1, 4, 12, 24, 48 and 72 h post-dose and then at Days 7, 14, 21 and 28. Median (range) baseline TGA peak level (a key coagulation-related clinical biomarker) of 9.20 (4.9-45.3) nmol in Chinese participants with severe haemophilia was similar to that seen in non-Asian patients with haemophilia ( I n i = 26).[7] The treatment-related trends in all PD endpoints were similar to those seen in healthy White participants[6] and non-Asian participants with severe haemophilia following administration of a single 300 mg dose of marstacimab.[7] No participants had positive ADAs at baseline. For severe haemophilia A or B (factor VIII [FVIII] or IX [FIX] activity levels <1% of normal [<1 IU/dL]), the main prophylaxis treatment is standard clotting factor concentrates (CFCs). Samples were collected at baseline (pre-dose on Day 1); 1, 4 and 12 h post-dose on Day 1; 24 h post-dose (Day 2); 48 h post-dose (Day 3); 72 h post-dose (Day 4); and at Days 7, 14, 21 and 28. [Extracted from the article] |
|
Copyright of Haemophilia is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
