دورية أكاديمية
Developmentally Arrested Basket/Stellate Cells in Postnatal Human Brain as Potential Tumor Cells of Origin for Cerebellar Hemangioblastoma in von Hippel-Lindau Patients
| العنوان: | Developmentally Arrested Basket/Stellate Cells in Postnatal Human Brain as Potential Tumor Cells of Origin for Cerebellar Hemangioblastoma in von Hippel-Lindau Patients |
|---|---|
| المؤلفون: | Shively, Sharon Baughman, Edwards, Nancy A, MacDonald, Tobey J, Johnson, Kory R, Diaz-Rodriguez, Natalia M, Merrill, Marsha J, Vortmeyer, Alexander O |
| المصدر: | GW Authored Works |
| بيانات النشر: | Health Sciences Research Commons |
| سنة النشر: | 2022 |
| المجموعة: | George Washington University: Health Sciences Research Commons (HSRC) |
| مصطلحات موضوعية: | Developmentally arrested basket/stellate cells, Hemangioblastoma, Paired box 2 (PAX2), Tumor suppressor syndrome, VHL human cerebellum tumor cell of origin, von Hippel-Lindau (VHL) disease |
| الوصف: | von Hippel-Lindau (VHL) disease is an autosomal dominant hereditary cancer disorder caused by a germline mutation in the VHL tumor suppressor gene. Loss of the wild-type allele results in VHL deficiency and the potential formation of cerebellar hemangioblastomas, which resemble embryonic hemangioblast proliferation and differentiation processes. Multiple, microscopic, VHL-deficient precursors, termed developmentally arrested structural elements (DASEs), consistently involve the cerebellar molecular layer in VHL patients, indicating the tumor site of origin. Unlike hemangioblastomas, however, cerebellar DASEs do not express brachyury, a mesodermal marker for hemangioblasts. In this study, neuronal progenitors occupying the molecular layer were investigated as tumor cells of origin. By immunohistochemistry, cerebellar DASEs and hemangioblastomas lacked immunoreactivity with antibody ZIC1 (Zic family member 1), a granule cell progenitor marker with concordance from oligonucleotide RNA expression array analyses. Rather, cerebellar DASEs and hemangioblastomas were immunoreactive with antibody PAX2 (paired box 2), a marker of basket/stellate cell progenitors. VHL cerebellar cortices also revealed PAX2-positive cells in Purkinje and molecular layers, resembling the histological and molecular development of basket/stellate cells in postnatal non-VHL mouse and human cerebella. These data suggest that VHL deficiency can result in the developmental arrest of basket/stellate cells in the human cerebellum and that these PAX2-positive, initiated cells await another insult or signal to form DASEs and eventually, tumors. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://hsrc.himmelfarb.gwu.edu/gwhpubs/1761Test; https://doi.org/10.1093/jnen/nlac073Test |
| DOI: | 10.1093/jnen/nlac073 |
| الإتاحة: | https://doi.org/10.1093/jnen/nlac073Test https://hsrc.himmelfarb.gwu.edu/gwhpubs/1761Test |
| رقم الانضمام: | edsbas.CD2D881F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/jnen/nlac073 |
|---|