Specificities of the intestinal microbiota in patients with inflammatory bowel disease and Clostridium difficile infection
| العنوان: | Specificities of the intestinal microbiota in patients with inflammatory bowel disease and Clostridium difficile infection |
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| المؤلفون: | Cécilia Landman, Anne Bourrier, Mathias L. Richard, Guillaume Le Gall, Isabelle Nion-Larmurier, Philippe Seksik, Sarah Jegou, Jacques Cosnes, Valentin Leducq, Claire McQuitty, Julien Kirchgesner, Harry Sokol, Marjolene Straub, Laurent Beaugerie |
| المساهمون: | Microorganismes, Molécules Bioactives et Physiopathologie Intestinale (LBM-E4), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Service de rhumatologie [CHU Saint-Antoine], CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Gastroentérologie et nutrition [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Biocodex, Service de rhumatologie, inflammation-immunopathologie- biothérapie [CHU Saint-Antoine] (DHU i2B ), CHU Saint-Antoine [APHP]-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Saint-Antoine [APHP], Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), HAL-UPMC, Gestionnaire, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) |
| المصدر: | Gut microbes Gut microbes, Taylor & Francis, 2017, 9 (1), pp.1-6. ⟨10.1080/19490976.2017.1361092⟩ Gut microbes, Taylor & Francis, 2017, pp.1-6. ⟨10.1080/19490976.2017.1361092⟩ Gut microbes, 2017, 9 (1), pp.1-6. ⟨10.1080/19490976.2017.1361092⟩ |
| بيانات النشر: | Informa UK Limited, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, genetic structures, IBD, digestive system, Microbiology, Gastroenterology, Inflammatory bowel disease, Feces, Young Adult, 03 medical and health sciences, Species Specificity, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Ruminococcus gnavus, Internal medicine, medicine, Humans, Bacteria, biology, Brief Report, Gastrointestinal Microbiome, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Biodiversity, Clostridium difficile, Middle Aged, Inflammatory Bowel Diseases, biology.organism_classification, medicine.disease, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, digestive system diseases, 3. Good health, Intestines, 030104 developmental biology, Infectious Diseases, Enterococcus, Immunology, Clostridium Infections, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Dysbiosis, Female, Complication |
| الوصف: | International audience; Background and Aims: Clostridium difficile infection (CDI) is a common complication in inflammatory bowel disease (IBD) and has been associated with poor IBD outcome. Intestinal microbiota composition in IBD patients with CDI has not been specifically evaluated to date.Methods: The fecal microbiota of 56 IBD patients, including 8 in flare with concomitant CDI, 24 in flare without CDI, and 24 in remission, as well as 24 healthy subjects, was studied using 16S sequencing. Analysis was performed using the Qiime pipeline.Results: Compared to IBD patients without CDI, IBD patients with CDI had more pronounced dysbiosis with higher levels of Ruminococcus gnavus and Enterococcus operational taxonomic units (OTUs) and lower levels of Blautia and Dorea OTUs. Correlation network analysis suggested a disrupted ecosystem in IBD patients in flare, particularly in those with CDI.Conclusions: In patients with IBD, CDI is associated with a more pronounced intestinal dysbiosis with specific alterations in intestinal microorganisms. |
| وصف الملف: | application/pdf |
| تدمد: | 1949-0984 1949-0976 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01041c9f2dbe9af9ed8cd95fe4dcc661Test https://doi.org/10.1080/19490976.2017.1361092Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....01041c9f2dbe9af9ed8cd95fe4dcc661 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19490984 19490976 |
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