Fiber mixture-specific effect on distal colonic fermentation and metabolic health in lean but not in prediabetic men
| العنوان: | Fiber mixture-specific effect on distal colonic fermentation and metabolic health in lean but not in prediabetic men |
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| المؤلفون: | Emanuel E. Canfora, Gerben D.A. Hermes, Mattea Müller, Jacco Bastings, Elaine E. Vaughan, Marco A. van Den Berg, Jens J. Holst, Koen Venema, Erwin G. Zoetendal, Ellen E. Blaak |
| المساهمون: | Humane Biologie, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, RS: FSE UCV Program - 1 - Lijn 1: Microbiological, RS: NUTRIM - R2 - Liver and digestive health |
| المصدر: | Gut Microbes, 14(1):2009297. Landes Bioscience Gut Microbes, 14(1) Gut Microbes 14 (2022) 1 Gut Microbes article-version (VoR) Version of Record Gut Microbes, Vol 14, Iss 1 (2022) Canfora, E E, Hermes, G D A, Mueller, M, Bastings, J, Vaughan, E E, van den Berg, M A, Holst, J J, Venema, K, Zoetendal, E G & Blaak, E E 2022, ' Fiber mixture-specific effect on distal colonic fermentation and metabolic health in lean but not in prediabetic men ', Gut Microbes, vol. 14, no. 1 . https://doi.org/10.1080/19490976.2021.2009297Test |
| بيانات النشر: | Landes Bioscience, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Adult, Dietary Fiber, Male, Microbiology (medical), Colon, RC799-869, PRJEB47404, OXIDATION, dietary fibers, Microbiology, DIET, Prediabetic State, Feces, Short-chain fatty acids, Thinness, ACETATE, Humans, MolEco, LARGE-INTESTINE, Aged, VLAG, Bacteria, gut microbiota, Inulin, Gastroenterology, Diseases of the digestive system. Gastroenterology, Middle Aged, Overweight, DEGRADATION, Fatty Acids, Volatile, Gastrointestinal Microbiome, METAGENOME, Infectious Diseases, CHAIN FATTY-ACIDS, OBESITY, Fermentation, substrate metabolism, ENRICHMENT, Research Article, Research Paper |
| الوصف: | Infusions of the short-chain fatty acid (SCFA) acetate in the distal colon improved metabolic parameters in men. Here, we hypothesized that combining rapidly and slowly fermentable fibers will enhance distal colonic acetate production and improve metabolic health. In vitro cultivation studies in a validated model of the colon were used to identify fiber mixtures that yielded high distal colonic acetate production. Subsequently, in two randomized crossover studies, lean and prediabetic overweight/obese men were included. In one study, participants received supplements of either long-chain inulin+resistant starch (INU+RS), INU or maltodextrin (PLA) the day prior to a clinical investigation day (CID). The second trial studied beta glucan+RS (BG+RS) versus BG and PLA. During each CID, breath hydrogen, indirect calorimetry, plasma metabolites/hormones were assessed during fasting and postprandial conditions. Additionally, fecal microbiota composition and SCFA were determined. In prediabetic men, INU+RS increased plasma acetate compared to INU or PLA (P < .05), but did not affect metabolic parameters. In lean men, INU+RS increased breath hydrogen and fasting plasma butyrate, which was accompanied by increased energy expenditure, carbohydrate oxidation and PYY and decreased postprandial glucose concentrations (all P < .05) compared to PLA. BG+RS increased plasma butyrate compared to PLA (P < .05) in prediabetic individuals, but did not affect other fermentation/metabolic markers in both phenotypes. Fiber-induced shifts in fecal microbiota were individual-specific and more pronounced with INU+RS versus BG+RS. Administration of INU+RS (not BG+RS) the day prior to investigation improved metabolic parameters in lean but not in prediabetic individuals, demonstrating that effects were phenotype- and fiber-specific. Further research should study whether longer-term supplementation periods are required to elicit beneficial metabolic health in prediabetic individuals. Trial registration numbers: Clinical trial No. NCT03711383 (Inulin study) and Clinical trial No. NCT03714646 (Beta glucan study). |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1949-0976 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7be3bf93572c37b828d37ee6cbaf47Test https://doi.org/10.1080/19490976.2021.2009297Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....be7be3bf93572c37b828d37ee6cbaf47 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19490976 |
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