التفاصيل البيبلوغرافية
| العنوان: |
Atrophic gastritis and intestinal metaplasia after H. pylori eradication: a long term follow-up. |
| المؤلفون: |
Rocco, A., Suriani, R., Venturini, I., Mazzucco, D., Nardone, G. |
| المصدر: |
Gut; Sep2002 Supplement 2, Vol. 51, pA43, 1/4p |
| مصطلحات موضوعية: |
STOMACH cancer, GASTRITIS, HELICOBACTER pylori infections |
| مستخلص: |
Gastric cancer can be considered the end result of a multistep process that usually starts as chronic gastritis and progresses through gastric atrophy, intestinal metaplasia and dysplasia. Atrophic gastritis and intestinal metaplasia, long-term consequences of Helicobacter pylori (H. pylori) infection, are regarded as predisposing factors for gastric cancer associated with Helicobacter pylori infection, and their severity appears to influence gastric cancer risk. However it is debatable whether or not bacterial eradication reverses these lesions. Our purpose was to determine the outcome of chronic gastritis after H. pylori eradication in a long-term follow-up. Fifty-four consecutive patients with duodenal ulcer and H. pylori infection were enrolled in the study. All patients received conventional eradication therapy (omeprazole 40 mg bid, amoxocyllin 1 g bid and clarithromycin 500 mg bid). Endoscopic examination with antral and corporal biopsy was done at baseline and at yearly intervals. The follow-up period ranged from 60 to 144 months. Gastritis, atrophy, and metaplasia were graded according to the updated Sydney System. Helicobacter pylori status was determined using a rapid urease test and modified Giemsa stain. Twenty-four patients were successfully treated; infection persisted in 14 and 16 dropped out (during the first five years of follow-up). Inflammation and mean neutrophil activity significantly decreased in patients in whom H. pylori was eradicated. Glandular atrophy improved in 2 and disappeared in 5/17 patients, whereas intestinal metaplasia inproved in 3 and disappeared in 2/12. In the patients in whom H. pylori persisted, inflammatory infiltrate, atrophy and intestinal metaplasia had not significantly decreased during follow-up. In contrast, glandular atrophy worsened in 2 and developed in 5/7 patients. Similarly, intestinal metaplasia did not improve when present and developed in 5/13 cases. In a long-term follow-up, H. pylori eradication does... [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
