Haller’s vessels patterns in non-neovascular age-related macular degeneration
| العنوان: | Haller’s vessels patterns in non-neovascular age-related macular degeneration |
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| المؤلفون: | Riccardo Sacconi, Maria Vittoria Cicinelli, Marco Casaluci, Bruno Lumbroso, Giuseppe Querques, Enrico Borrelli, Marco Rispoli, Eleonora Corbelli, Francesco Bandello, Maria Cristina Savastano |
| المساهمون: | Sacconi, R., Cicinelli, M. V., Borrelli, E., Savastano, M. C., Rispoli, M., Lumbroso, B., Corbelli, E., Casaluci, M., Bandello, F., Querques, G. |
| المصدر: | Graefe's Archive for Clinical and Experimental Ophthalmology. 258:2163-2171 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Reticular pseudodrusen, genetic structures, Retinal Drusen, Drusen, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Geographic Atrophy, Ophthalmology, Age related, En face optical coherence tomography, medicine, Humans, In patient, Fluorescein Angiography, Tomography, Retrospective Studies, Choroid, business.industry, Settore MED/30 - MALATTIE APPARATO VISIVO, Age-related macular degeneration, Macular degeneration, medicine.disease, eye diseases, Sensory Systems, Geographic atrophy, 030104 developmental biology, medicine.anatomical_structure, Optical Coherence, Reticular connective tissue, 030221 ophthalmology & optometry, sense organs, business, Choroidal patterns, Tomography, Optical Coherence |
| الوصف: | Purpose: To investigate the optical coherence tomography (OCT) en face reconstruction of the choroid in different phenotypes of non-neovascular age-related macular degeneration (AMD), to identify the relative distribution of the vascular patterns of the Haller’s layer in each AMD category. Methods: Retrospective study enrolling consecutive patients with non-neovascular AMD. Patients were divided into the following: (1) those with reticular pseudodrusen (RPD); (2) those with small (< 63μm) or medium–large drusen (63–124μm); (3) those with geographic atrophy (GA). Qualitative analysis of the en face images provided by CIRRUS HD-OCT 5000 (Carl Zeiss Meditech, Inc., Dublin, USA) was performed, identifying five arrangements of Haller’s vessels: temporal herringbone, branched from below, laterally diagonal, double arcuate, and reticular. Choroidal thickness (CT) was measured from structural OCT. Healthy age-matched subjects were included as a control group. Results: Fifty-eight eyes of 58 patients (20 eyes with RPD; 22 eyes with drusen; 16 eyes with GA) and 18 control eyes were enrolled. The laterally diagonal configuration was the most prevalent (40.0%) in the RPD group; the reticular pattern was the most frequent in the drusen group (50.0%); the double arcuate (62.5%) was the most recurrent pattern in patients with GA. In the control group, the temporal herringbone (38.9%) arrangement was the most represented. The CT associated with the temporal herringbone and reticular arrangement was significantly higher compared to the branched from below (p < 0.001), the laterally diagonal (p = 0.014), and the double arcuate pattern (p = 0.009). Conclusion: Different phenotypes of non-neovascular AMD present a specific distribution of vascular arrangement on en face OCT. The temporal herringbone and the reticular pattern (the ones more associated in a physiological setting) disclosed a thicker choroid compared to the arrangements more represented in non-neovascular AMD-correlated phenotypes. |
| تدمد: | 1435-702X 0721-832X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca91656b05fff769b0be6b336d0172fTest https://doi.org/10.1007/s00417-020-04769-7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bca91656b05fff769b0be6b336d0172f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1435702X 0721832X |
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