التفاصيل البيبلوغرافية
| العنوان: |
Exploring the characteristics of sequence elements in proximal promoters of human genes |
| المؤلفون: |
Bina, Minou Bina@Purdue.edu, Wyss, Phillip1, Ren, Wenhui2, Szpankowski, Wojciech2, Thomas, Elizabeth3, Randhawa, Ranjit1, Reddy, Sreedeepti1, John, Priya M.1, Pares-Matos, Elsie I.1, Stein, Arnold4, Xu, Hao1, Lazarus, Sheryl A.1 |
| المصدر: |
Genomics. Dec2004, Vol. 84 Issue 6, p929-940. 12p. |
| مصطلحات موضوعية: |
*HUMAN gene mapping, *HUMAN genome, *DNA, *TRANSCRIPTION factors |
| مستخلص: |
Central to reconstruction of cis-regulatory networks is identification and classification of naturally occurring transcription factor-binding sites according to the genes that they control. We have examined salient characteristics of 9-mers that occur in various orders and combinations in the proximal promoters of human genes. In evaluations of a dataset derived with respect to experimentally defined transcription initiation sites, in some cases we observed a clear correspondence of highly ranked 9-mers with protein-binding sites in genomic DNA. Evaluations of the larger dataset, derived with respect to the 5′ end of human ESTs, revealed that a subset of the highly ranked 9-mers corresponded to sites for several known transcription factor families (including CREB, ETS, EGR-1, SP1, KLF, MAZ, HIF-1, and STATs) that play important roles in the regulation of vertebrate genes. We identified several highly ranked CpG-containing 9-mers, defining sites for interactions with the CREB and ETS families of proteins, and identified potential target genes for these proteins. The results of the studies imply that the CpG-containing transcription factor-binding sites regulate the expression of genes with important roles in pathways leading to cell-type-specific gene expression and pathways controlled by the complex networks of signaling systems. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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