التفاصيل البيبلوغرافية
| العنوان: |
Similar Ratios of Introns to Intergenic Sequence across Animal Genomes. |
| المؤلفون: |
Francis, Warren R.1 woerheide@lmu.de, Wörheide, Gert1,2,3 |
| المصدر: |
Genome Biology & Evolution. Jun2017, Vol. 9 Issue 6, p1582-1598. 17p. |
| مصطلحات موضوعية: |
*INTRONS, *COMPLEMENTATION (Genetics), *GENOMES, *EUKARYOTES, *GENOME size, *NON-coding DNA |
| مستخلص: |
One central goal of genome biology is to understand howthe usage of the genome differs between organisms. Our knowledge of genomecomposition, needed fordownstream inferences, is critically dependent on gene annotations, yet problems associated with gene annotation and assembly errors are usually ignored in comparative genomics. Here, we analyze the genomes of 68 species across 12 animal phyla and some single-cell eukaryotes for general trends in genome composition and transcription, taking into account problems of gene annotation. We show that, regardless of genome size, the ratio of introns to intergenic sequence is comparable across essentially all animals, with nearly all deviations dominated by increased intergenic sequence. Genomes of model organisms have ratios much closer to 1:1, suggesting that the majority of published genomes of nonmodel organisms are underannotated and consequentlyomit substantial numbers of genes, with likely negative impact on evolutionary interpretations. Finally, our results also indicate that most animals transcribe half or more of their genomes arguing against differences in genome usage between animal groups, and also suggesting that the transcribed portion is more dependent on genome size than previously thought. [ABSTRACT FROM AUTHOR] |
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