Molecular mechanisms of regulation of HTLV-1 gene expression and its association with leukemogenesis
| العنوان: | Molecular mechanisms of regulation of HTLV-1 gene expression and its association with leukemogenesis |
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| المؤلفون: | Jun-ichi Fujisawa, Jun-ichiro Inoue, Motoharu Seiki, Mitsuaki Yoshida |
| المصدر: | Genome. 31:662-667 |
| بيانات النشر: | Canadian Science Publishing, 1989. |
| سنة النشر: | 1989 |
| مصطلحات موضوعية: | Gene Expression Regulation, Viral, Transcriptional Activation, RNA Splicing, viruses, Retroviridae Proteins, Oncogenic, Retroviridae Proteins, Regulator, Biology, Virus Replication, Cell Line, Transcription (biology), Gene expression, Genetics, Animals, Humans, Leukemia-Lymphoma, Adult T-Cell, Molecular Biology, Gene, Regulator gene, Human T-lymphotropic virus 1, Messenger RNA, Gene Expression Regulation, Leukemic, Receptors, Interleukin-2, Gene Products, tax, General Medicine, Long terminal repeat, Rats, RNA splicing, Trans-Activators, Transcription Factors, Biotechnology |
| الوصف: | Human T-cell leukemia virus type 1 (HTLV-1) has two trans-acting regulator genes, tax and rex, in the pX region. The tax gene is a trans-acting transcriptional activator of the long terminal repeat (LTR) and also of the cellular gene for IL-2Rα. The latter seems to explain initiation of abnormal growth of HTLV-1 infected cells. The rex gene is a posttranscriptional regulator accumulating gag and env mRNA and also indirectly suppressing the transcription. The regulation requires two cis-acting elements, the LTR sequence at the 3′ terminus and 5′ splice signal, suggesting a novel mechanism of RNA processing in the nucleus. These two trans-activator genes are essential for efficient replication of HTLV-1 and also explain its poor replication competence and tendency to be latent in vivo.Key words: HTLV-1, trans-activation, posttranscriptional regulation, RNA splicing. |
| تدمد: | 1480-3321 0831-2796 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57df218ae5c32c1fb599789c056134b9Test https://doi.org/10.1139/g89-121Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....57df218ae5c32c1fb599789c056134b9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14803321 08312796 |
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