دورية أكاديمية
Whole-genome sequencing of European autochthonous and commercial pig breeds allows the detection of signatures of selection for adaptation of genetic resources to different breeding and production systems
| العنوان: | Whole-genome sequencing of European autochthonous and commercial pig breeds allows the detection of signatures of selection for adaptation of genetic resources to different breeding and production systems |
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| المؤلفون: | Samuele Bovo, Anisa Ribani, Maria Muñoz, Estefania Alves, Jose P. Araujo, Riccardo Bozzi, Marjeta Čandek-Potokar, Rui Charneca, Federica Di Palma, Graham Etherington, Ana I. Fernandez, Fabián García, Juan García-Casco, Danijel Karolyi, Maurizio Gallo, Vladimir Margeta, José Manuel Martins, Marie J. Mercat, Giulia Moscatelli, Yolanda Núñez, Raquel Quintanilla, Čedomir Radović, Violeta Razmaite, Juliette Riquet, Radomir Savić, Giuseppina Schiavo, Graziano Usai, Valerio J. Utzeri, Christoph Zimmer, Cristina Ovilo, Luca Fontanesi |
| المصدر: | Genetics Selection Evolution, Vol 52, Iss 1, Pp 1-19 (2020) |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Animal culture LCC:Genetics |
| مصطلحات موضوعية: | Animal culture, SF1-1100, Genetics, QH426-470 |
| الوصف: | Abstract Background Natural and artificial directional selection in cosmopolitan and autochthonous pig breeds and wild boars have shaped their genomes and resulted in a reservoir of animal genetic diversity. Signatures of selection are the result of these selection events that have contributed to the adaptation of breeds to different environments and production systems. In this study, we analysed the genome variability of 19 European autochthonous pig breeds (Alentejana, Bísara, Majorcan Black, Basque, Gascon, Apulo-Calabrese, Casertana, Cinta Senese, Mora Romagnola, Nero Siciliano, Sarda, Krškopolje pig, Black Slavonian, Turopolje, Moravka, Swallow-Bellied Mangalitsa, Schwäbisch-Hällisches Schwein, Lithuanian indigenous wattle and Lithuanian White old type) from nine countries, three European commercial breeds (Italian Large White, Italian Landrace and Italian Duroc), and European wild boars, by mining whole-genome sequencing data obtained by using a DNA-pool sequencing approach. Signatures of selection were identified by using a single-breed approach with two statistics [within-breed pooled heterozygosity (HP) and fixation index (FST)] and group-based FST approaches, which compare groups of breeds defined according to external traits and use/specialization/type. Results We detected more than 22 million single nucleotide polymorphisms (SNPs) across the 23 compared populations and identified 359 chromosome regions showing signatures of selection. These regions harbour genes that are already known or new genes that are under selection and relevant for the domestication process in this species, and that affect several morphological and physiological traits (e.g. coat colours and patterns, body size, number of vertebrae and teats, ear size and conformation, reproductive traits, growth and fat deposition traits). Wild boar related signatures of selection were detected across all the genome of several autochthonous breeds, which suggests that crossbreeding (accidental or deliberate) occurred with wild boars. Conclusions Our findings provide a catalogue of genetic variants of many European pig populations and identify genome regions that can explain, at least in part, the phenotypic diversity of these genetic resources. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | German English French |
| تدمد: | 1297-9686 |
| العلاقة: | http://link.springer.com/article/10.1186/s12711-020-00553-7Test; https://doaj.org/toc/1297-9686Test |
| DOI: | 10.1186/s12711-020-00553-7 |
| الوصول الحر: | https://doaj.org/article/afd7a7923e6f4976a72fafb4aa11b765Test |
| رقم الانضمام: | edsdoj.fd7a7923e6f4976a72fafb4aa11b765 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 12979686 |
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| DOI: | 10.1186/s12711-020-00553-7 |