Linking dopamine neurotransmission and neurogenesis: the evolutionary history of the NTAD (NCAM1-TTC12-ANKK1-DRD2) gene cluster
| العنوان: | Linking dopamine neurotransmission and neurogenesis: the evolutionary history of the NTAD (NCAM1-TTC12-ANKK1-DRD2) gene cluster |
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| المؤلفون: | Eli Vieira Araujo-Jnr, Nina Roth Mota, Maria Cátira Bortolini, Vanessa Rodrigues Paixão-Côrtes, Claiton H.D. Bau |
| المصدر: | Genetics and Molecular Biology, Volume: 35, Issue: 4 Supplement 1, Pages: 912-918, Published: 2012 Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS Genetics and Molecular Biology, Vol 35, Iss 4, Pp 912-918 (2012) Genetics and Molecular Biology v.35 n.4 suppl.1 2012 Genetics and Molecular Biology Sociedade Brasileira de Genética (SBG) instacron:SBG |
| بيانات النشر: | FapUNIFESP (SciELO), 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Drd2 gene, Genetics, co-regulation, ANKK1, lcsh:QH426-470, Neurogenesis, Neurogênese, myr, Dopamina, shared synteny, Single-nucleotide polymorphism, Biology, Disease cluster, Transtornos mentais, psychiatric genetics, lcsh:Genetics, Psiquiatria, Taq1A SNP, Neurotransmissores, NTAD cluster, Molecular Biology, Gene, Psychiatric genetics, Research Article |
| الوصف: | Genetic studies have long suggested the important role of the DRD2 gene in psychiatric disorders and behavior. Further research has shown a conjoined effect of genes in the Chr11q22-23 region, which includes the NCAM1, TTC12, ANKK1 and DRD2 genes, or NTAD cluster. Despite a growing need to unravel the role of this cluster, few studies have taken into account interspecies and evolutionary approaches. This study shows that behaviorally relevant SNPs from the NTAD cluster, such as rs1800497 (Taq1A) and rs6277, are ancient polymorphisms that date back to the common ancestor between modern humans and Neanderthals/Denisovans. Conserved synteny and neighborhood indicate the NTAD cluster seems to have been established at least 400 million years ago, when the first Sarcopterygians emerged. The NTAD genes are apparently co-regulated and this could be attributed to adaptive functional properties, including those that emerged when the central nervous system became more complex. Finally, our findings indicate that NTAD genes, which are related to neurogenesis and dopaminergic neurotransmission, should be approached as a unit in behavioral and psychiatric genetic studies. |
| وصف الملف: | text/html; application/pdf |
| تدمد: | 1415-4757 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00de0f822c1f4a87d9a22f7f3fbd2dcfTest https://doi.org/10.1590/s1415-47572012000600004Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....00de0f822c1f4a87d9a22f7f3fbd2dcf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14154757 |
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