التفاصيل البيبلوغرافية
| العنوان: |
CCR5-Δ32 genotype does not improve predictive value of IL28B polymorphisms for treatment response in chronic HCV infection. |
| المؤلفون: |
Suppiah, V1, Armstrong, N J2, O'Connor, K S3, Berg, T4, Weltman, M5, Abate, M L6, Spengler, U7, Bassendine, M8, Dore, G J9, Irving, W L10, Powell, E11, Nattermann, J7, Mueller, T4, Riordan, S12, Stewart, G J3, George, J13, Booth, D R3, Ahlenstiel, G14, Michalk, Monika, Malik, Barbara |
| المصدر: |
Genes & Immunity. Jul2013, Vol. 14 Issue 5, p286-290. 5p. 4 Charts, 1 Graph. |
| مصطلحات موضوعية: |
*CHEMOKINE receptors, *INTERLEUKIN-2, *GENETIC polymorphisms, *CHRONIC hepatitis C, *RIBAVIRIN, *INTERFERONS, *VIROLOGY, *THERAPEUTICS |
| مستخلص: |
IL28B polymorphisms strongly predict spontaneous and treatment-induced clearance of hepatitis C virus (HCV) infection. A recent study proposed a 32-base pair deletion in the CC-chemokine receptor 5 (CCR5) gene (CCR5-Δ32) interacting with the IL28B polymorphisms to influence spontaneous HCV clearance. The aim of this study was to clarify the role of CCR5-Δ32 in treatment-induced clearance of chronic hepatitis C (CHC). A cross-sectional cohort of 813 Caucasian patients with CHC genotype 1 (365 responders and 448 non-responders) who had received standard of care dual therapy with interferon (IFN)-α and ribavirin (RBV) was genotyped for the CCR5-Δ32 and IL28B polymorphisms to examine their interaction with respect to treatment response. CCR5-Δ32 did not influence treatment-induced recovery to IFN-α/RBV in CHC, and did not improve prediction of sustained virological response in the context of the IL28B polymorphisms in a multivariate model. CCR5-Δ32 homozygotes were significantly more frequent in those with CHC than healthy controls in the European cohorts (2.9% vs 0.4%, P<0.0001), but not in Australians of European ancestry. In conclusion, CCR5-Δ32 does not influence treatment response in the context of IL28B polymorphisms. Although CCR5-Δ32 may affect viral clearance within closely controlled geographical and genetic environments, we found no effect in larger cohorts treated with dual therapy. [ABSTRACT FROM AUTHOR] |
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