Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides
| العنوان: | Food-derived sensory cues modulate longevity via distinct neuroendocrine insulin-like peptides |
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| المؤلفون: | Zahabiya Husain, Ozlem Altintas, Joy Alcedo, Jinmahn Kim, Heehwa G. Son, Kyuhyung Kim, Young Il Kim, Dongyeop Lee, Seung-Jae Lee, Dae-Eun Jeong, Murat Artan |
| المصدر: | Genes & Development. 30:1047-1057 |
| بيانات النشر: | Cold Spring Harbor Laboratory, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Sensory Receptor Cells, Peptide Hormones, media_common.quotation_subject, Longevity, Sensory system, Environment, Optogenetics, 03 medical and health sciences, Genetics, Daf-16, Insulin, Caenorhabditis elegans Proteins, Sensory cue, Caenorhabditis elegans, media_common, Regulation of gene expression, biology, Forkhead Transcription Factors, Anatomy, biology.organism_classification, 030104 developmental biology, Gene Expression Regulation, Food, Cues, Neuroscience, Research Paper, Signal Transduction, Developmental Biology |
| الوصف: | Environmental fluctuations influence organismal aging by affecting various regulatory systems. One such system involves sensory neurons, which affect life span in many species. However, how sensory neurons coordinate organismal aging in response to changes in environmental signals remains elusive. Here, we found that a subset of sensory neurons shortens Caenorhabditis elegans’ life span by differentially regulating the expression of a specific insulin-like peptide (ILP), INS-6. Notably, treatment with food-derived cues or optogenetic activation of sensory neurons significantly increases ins-6 expression and decreases life span. INS-6 in turn relays the longevity signals to nonneuronal tissues by decreasing the activity of the transcription factor DAF-16/FOXO. Together, our study delineates a mechanism through which environmental sensory cues regulate aging rates by modulating the activities of specific sensory neurons and ILPs. |
| تدمد: | 1549-5477 0890-9369 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217982367af5e39e827bfaa528aba660Test https://doi.org/10.1101/gad.279448.116Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....217982367af5e39e827bfaa528aba660 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15495477 08909369 |
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