The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans
| العنوان: | The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans |
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| المؤلفون: | Martha C. Soto, Craig C. Mello, Daisuke Tsuboi, Katsuhisa Kasuya, Makiko Inoue, Hiroshi Qadota, Kozo Kaibuchi |
| المصدر: | Genes & Development. 16:620-632 |
| بيانات النشر: | Cold Spring Harbor Laboratory, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Oviposition, Cellular differentiation, Molecular Sequence Data, Morphogenesis, Body morphogenesis, Cell Movement, Genetics, Animals, Drosophila Proteins, Small GTPase, Amino Acid Sequence, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Conserved Sequence, Genes, Helminth, Adaptor Proteins, Signal Transducing, Sequence Homology, Amino Acid, biology, Embryo, biology.organism_classification, Cell Compartmentation, rac GTP-Binding Proteins, Cell biology, Rac GTP-Binding Proteins, Carrier Proteins, Drosophila Protein, Research Paper, Developmental Biology |
| الوصف: | During body morphogenesis precisely coordinated cell movements and cell shape changes organize the newly differentiated cells of an embryo into functional tissues. Here we describe two genes, gex-2 andgex-3, whose activities are necessary for initial steps of body morphogenesis in Caenorhabditis elegans. In the absence ofgex-2 and gex-3 activities, cells differentiate properly but fail to become organized. The external hypodermal cells fail to spread over and enclose the embryo and instead cluster on the dorsal side. Postembryonically gex-3 activity is required for egg laying and for proper morphogenesis of the gonad. GEX-2 and GEX-3 proteins colocalize to cell boundaries and appear to directly interact. GEX-2 and GEX-3 are highly conserved, with vertebrate homologs implicated in binding the small GTPase Rac and a GEX-3Drosophila homolog, HEM2/NAP1/KETTE, that interacts genetically with Rac pathway mutants. Our findings suggest that GEX-2 and GEX-3 may function at cell boundaries to regulate cell migrations and cell shape changes required for proper morphogenesis and development. |
| تدمد: | 1549-5477 0890-9369 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ee9e0f5688384c8c8b29f73a945b1eTest https://doi.org/10.1101/gad.955702Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....75ee9e0f5688384c8c8b29f73a945b1e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15495477 08909369 |
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