Mechanisms of Hippo pathway regulation
| العنوان: | Mechanisms of Hippo pathway regulation |
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| المؤلفون: | Kun-Liang Guan, Zhipeng Meng, Toshiro Moroishi |
| المصدر: | Genes & development, vol 30, iss 1 |
| بيانات النشر: | Cold Spring Harbor Laboratory, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Enzymologic, TAZ, 0301 basic medicine, endocrine system, animal structures, 1.1 Normal biological development and functioning, LATS, Review, Protein Serine-Threonine Kinases, Biology, Medical and Health Sciences, Gene Expression Regulation, Enzymologic, 03 medical and health sciences, Underpinning research, Cell polarity, Genetics, Animals, Humans, TEAD1, Transcription factor, MST, Hippo signaling pathway, MAP4K, TEAD, Cell growth, Psychology and Cognitive Sciences, fungi, Biological Sciences, Actin cytoskeleton, Cell biology, body regions, Drosophila melanogaster, 030104 developmental biology, Gene Expression Regulation, Hippo signaling, sense organs, YAP, Generic health relevance, Signal transduction, Transcription Factors, Signal Transduction, Biotechnology, Developmental Biology |
| الوصف: | The Hippo pathway was initially identified in Drosophila melanogaster screens for tissue growth two decades ago and has been a subject extensively studied in both Drosophila and mammals in the last several years. The core of the Hippo pathway consists of a kinase cascade, transcription coactivators, and DNA-binding partners. Recent studies have expanded the Hippo pathway as a complex signaling network with >30 components. This pathway is regulated by intrinsic cell machineries, such as cell–cell contact, cell polarity, and actin cytoskeleton, as well as a wide range of signals, including cellular energy status, mechanical cues, and hormonal signals that act through G-protein-coupled receptors. The major functions of the Hippo pathway have been defined to restrict tissue growth in adults and modulate cell proliferation, differentiation, and migration in developing organs. Furthermore, dysregulation of the Hippo pathway leads to aberrant cell growth and neoplasia. In this review, we focus on recent developments in our understanding of the molecular actions of the core Hippo kinase cascade and discuss key open questions in the regulation and function of the Hippo pathway. |
| وصف الملف: | application/pdf |
| تدمد: | 1549-5477 0890-9369 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c77ed0bc1658205e4cb9f9a7e594dedTest https://doi.org/10.1101/gad.274027.115Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2c77ed0bc1658205e4cb9f9a7e594ded |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15495477 08909369 |
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