Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth
| العنوان: | Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth |
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| المؤلفون: | Kun-Liang Guan, Da-Hye Lee, Ja Hyun Koo, Cun-Yu Wang, Dae-Sik Lim, Di Yang, Steven W. Plouffe, Zhipeng Meng |
| المصدر: | Genes Dev Genes & development, vol 34, iss 1-2 |
| بيانات النشر: | Cold Spring Harbor Laboratory, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Uveal Neoplasms, medicine.disease_cause, Medical and Health Sciences, Mice, 0302 clinical medicine, Hippo, Transcription (biology), 2.1 Biological and endogenous factors, Aetiology, Promoter Regions, Genetic, Melanoma, Tissue homeostasis, 0303 health sciences, Tumor, Adaptor Proteins, Genes, fos, Organ Size, Biological Sciences, Cell biology, Gene Expression Regulation, Neoplastic, Liver, 030220 oncology & carcinogenesis, Stem Cell Research - Nonembryonic - Non-Human, bilirubin, Biotechnology, Research Paper, c-fos, fos, Biology, liver, Cell Line, Promoter Regions, 03 medical and health sciences, hepatomegaly, Rare Diseases, Genetic, Cell Line, Tumor, Genetics, medicine, cancer, Animals, Humans, Transcription factor, Adaptor Proteins, Signal Transducing, Cell Proliferation, 030304 developmental biology, Neoplastic, Hippo signaling pathway, Cell growth, Human Genome, Psychology and Cognitive Sciences, Signal Transducing, YAP-Signaling Proteins, Promoter, Stem Cell Research, Transcription Factor AP-1, HEK293 Cells, Gene Expression Regulation, Genes, Transcriptional Coactivator with PDZ-Binding Motif Proteins, Cancer cell, Trans-Activators, Mitogens, Carcinogenesis, Gene Deletion, Transcription Factors, Developmental Biology |
| الوصف: | Yes-associated protein (YAP) and its homolog transcriptional coactivator with PDZ-binding motif (TAZ) are key effectors of the Hippo pathway to control cell growth and organ size, of which dysregulation yields to tumorigenesis or hypertrophy. Upon activation, YAP/TAZ translocate into the nucleus and bind to TEAD transcription factors to promote transcriptional programs for proliferation or cell specification. Immediate early genes, represented by AP-1 complex, are rapidly induced and control later-phase transcriptional program to play key roles in tumorigenesis and organ maintenance. Here, we report that YAP/TAZ directly promote FOS transcription that in turn contributes to the biological function of YAP/TAZ. YAP/TAZ bind to the promoter region of FOS to stimulate its transcription. Deletion of YAP/TAZ blocks the induction of immediate early genes in response to mitogenic stimuli. FOS induction contributes to expression of YAP/TAZ downstream target genes. Genetic deletion or chemical inhibition of AP-1 suppresses growth of YAP-driven cancer cells, such as Lats1/2-deficient cancer cells as well as Gαq/11 mutated uveal melanoma. Furthermore, AP-1 inhibition almost completely abrogates the hepatomegaly induced by YAP overexpression. Our findings reveal a feed-forward interplay between immediate early transcription of AP-1 and Hippo pathway function. |
| وصف الملف: | application/pdf |
| تدمد: | 1549-5477 0890-9369 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4932433e75f0c2b2317020a98402584Test https://doi.org/10.1101/gad.331546.119Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b4932433e75f0c2b2317020a98402584 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15495477 08909369 |
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