IL-6 Polymorphisms Are Not Related to Obesity Parameters in Physically Active Young Men
| العنوان: | IL-6 Polymorphisms Are Not Related to Obesity Parameters in Physically Active Young Men |
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| المؤلفون: | Kinga Humińska-Lisowska, Anna Cywińska, Andrzej Mastalerz, Paweł Cięszczyk, Aleksandra Garbacz, Katarzyna Lorenz, Ewelina Maculewicz, Ewa Szarska, Agnieszka Białek, Anna Borecka, Oktawiusz Antkowiak, Monika Michałowska-Sawczyn, Łukasz Dziuda, Bożena Antkowiak |
| المصدر: | Genes Volume 12 Issue 10 Genes, Vol 12, Iss 1498, p 1498 (2021) National Information Processing Institute |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Population, Single-nucleotide polymorphism, body mass index, QH426-470, Article, genetic polymorphisms, Internal medicine, Genetics, Genetic predisposition, medicine, Interleukin 6, education, Genetics (clinical), education.field_of_study, biology, business.industry, Lipid metabolism, IL6, medicine.disease, Obesity, Endocrinology, fat percentage, biology.protein, business, Body mass index, Hormone |
| الوصف: | Interleukin 6 (IL-6) is a cytokine with both pro- and anti-inflammatory actions, but is also considered as a “metabolic hormone” involved in immune responses, affecting glucose, protein and lipid metabolism. It has been proposed to be related to obesity, but various results have been presented. Thus, in this study, the very homogenous population of young, male military professionals, living in the same conditions involving high physical activity, has been selected to avoid the influence of environmental factors. The subjects were divided into groups depending on the obesity parameters BMI (body mass index) and fat percentage (fat%), and the following IL-6 SNPs (Single Nucleotide Polymorphisms) were analyzed: rs1800795, rs1800796 and rs13306435. No relation was found between obesity parameters and IL-6 polymorphisms rs1800795, rs1800796 and rs13306435. It may be postulated that even if a genetic predisposition involves IL-6 genes, this effect in individuals with obesity of a low grade is minor, or can be avoided or at least markedly reduced by changes in lifestyle. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2073-4425 |
| DOI: | 10.3390/genes12101498 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f39db1735b68be45932240d4fb7729Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....78f39db1735b68be45932240d4fb7729 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734425 |
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| DOI: | 10.3390/genes12101498 |