التفاصيل البيبلوغرافية
| العنوان: |
A thrombin inhibitor from the ixodid tick, Amblyomma hebraeum |
| المؤلفون: |
Lai, Ren1, Takeuchi, Hajime1, Jonczy, Jan2, Rees, Huw H. reeshh@liv.ac.uk, Turner, Philip C.1 |
| المصدر: |
Gene. Nov2004, Vol. 342 Issue 2, p243-249. 7p. |
| مصطلحات موضوعية: |
*ANTITHROMBINS, *AMINO acids, *AMBLYOMMA, *DNA, *THROMBIN |
| مستخلص: |
A novel thrombin inhibitor named Amblin was identified from the haemolymph of the ixodid (hard) tick, Amblyomma hebraeum, and the coding cDNA was isolated from a tick cDNA library. This cDNA codes for a preprotein of 166 amino acids, including a predicted signal peptide composed of 15 amino acids N-terminal to the mature Amblin. The 151-amino-acid mature Amblin contains 14 cysteines and two Kunitz-like domains. It displays high sequence similarity with a tissue factor pathway inhibitor (TFPI), Ixolaris, from the ixodid tick, Ixodes scapularis, which has 10 cysteines, and a thrombin inhibitor, Boophilin, from the ixodid tick, Boophilus microplus, which has 12 cysteines. Recombinant Amblin specifically inhibited thrombin as efficiently as native Amblin did. This is the first report of a thrombin inhibitor from tick haemolymph. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
Academic Search Index |
