دورية أكاديمية
Tau-Marin Mucoadhesive Gel for Prevention and Treatment of Gum Diseases
| العنوان: | Tau-Marin Mucoadhesive Gel for Prevention and Treatment of Gum Diseases |
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| المؤلفون: | Giuseppe Giannini, Irene Ragusa, Giulia Nerina Nardone, Sara Soldi, Marina Elli, Piera Valenti, Luigi Rosa |
| المصدر: | Gels, Vol 9, Iss 8, p 607 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Science LCC:Chemistry LCC:Inorganic chemistry LCC:General. Including alchemy |
| مصطلحات موضوعية: | Tau-Marin, mucoadhesive gel, oral formulation, probiotics, periodontitis, periodontal diseases, Science, Chemistry, QD1-999, Inorganic chemistry, QD146-197, General. Including alchemy, QD1-65 |
| الوصف: | An innovative and stable probiotic-containing mucoadhesive gel (AL0020), integrated with botanical extracts, has been developed to rebalance the dysbiosis associated with periodontal diseases. Tau-Marin gel, prepared with anhydrous ingredients to prevent the replication of bacteria and ensure good stability over time, was tested against some pathogenic bacteria, belonging to the so-called “red complex”, recognized as the most important pathogens in plaque specimens, adherent to the epithelial lining of periodontal pockets. This lipogel was tested in vitro, in a physiological solution (PS) and in a simulated saliva (SS), for up to 8 h, to monitor its ability to release probiotics over time. Probiotics were enumerated through two different techniques, Lacto-Counter Assay (LCA) and Colony Forming Unit (CFU). A detailed physico-chemical profile of AL0020 and its in vitro efficacy in protecting activity against pathogenic bacteria as well as soothing or irritative effect on gingival epithelium were reported. Moreover, a clinical-dermatological trial on 20 volunteers using the product once a day for 30 days was also performed, where the efficacy of the gel in the control of gum disorders was observed. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2310-2861 |
| العلاقة: | https://www.mdpi.com/2310-2861/9/8/607Test; https://doaj.org/toc/2310-2861Test |
| DOI: | 10.3390/gels9080607 |
| الوصول الحر: | https://doaj.org/article/4d3f2839fdcf4970ad85a9ccee41689eTest |
| رقم الانضمام: | edsdoj.4d3f2839fdcf4970ad85a9ccee41689e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23102861 |
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| DOI: | 10.3390/gels9080607 |