Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis
| العنوان: | Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis |
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| المؤلفون: | Weismueller, T, Strassburg, C, Trivedi, P, Hirschfield, G, Bergquist, A, Said, K, Imam, M, Lazaridis, K, Juran, B, Cheung, A, Lindor, K, Lenzen, H, Manns, M, Ponsioen, C, Beuers, U, Holm, K, Naess, S, Karlsen, T, Schrumpf, E, Boberg, K, Gotthardt, D, Rupp, C, Faerkkilae, M, Jokelainen, K, Marschall, H, Benito De Valle, M, Thorburn, D, Saffioti, F, Weersma, R, Fevery, J, Mueller, T, Chazouillãres, O, Schulze, K, Schramm, C, Almer, S, Pereira, S, Levy, C, Mason, A, Bowlus, C, Floreani, A, Halilbasic, E, Trauner, M, Yimam, K, Milkiewicz, P, Huynh, D, Pares, A, Manser, C, Dalekos, G, Eksteen, B, INVERNIZZI, PIETRO, Berg, C, Kirchner, G, Sarrazin, C, Zimmer, V, Fabris, L, Braun, F, Marzioni, M, Chapman, R, Hansen, B, Hansen, B. |
| المساهمون: | AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Gastroenterology and Hepatology, Weismueller, T, Strassburg, C, Trivedi, P, Hirschfield, G, Bergquist, A, Said, K, Imam, M, Lazaridis, K, Juran, B, Cheung, A, Lindor, K, Lenzen, H, Manns, M, Ponsioen, C, Beuers, U, Holm, K, Naess, S, Karlsen, T, Schrumpf, E, Boberg, K, Gotthardt, D, Rupp, C, Faerkkilae, M, Jokelainen, K, Marschall, H, Benito De Valle, M, Thorburn, D, Saffioti, F, Weersma, R, Fevery, J, Mueller, T, Chazouillãres, O, Schulze, K, Schramm, C, Almer, S, Pereira, S, Levy, C, Mason, A, Bowlus, C, Floreani, A, Halilbasic, E, Trauner, M, Yimam, K, Milkiewicz, P, Huynh, D, Pares, A, Manser, C, Dalekos, G, Eksteen, B, Invernizzi, P, Berg, C, Kirchner, G, Sarrazin, C, Zimmer, V, Fabris, L, Braun, F, Marzioni, M, Chapman, R, Hansen, B, Clinicum, Department of Medicine, Gastroenterologian yksikkö, HUS Abdominal Center, Universitat de Barcelona, Gastroenterology & Hepatology, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI) |
| المصدر: | Gastroenterology, 152(8), 1975-1984.e8. W.B. Saunders Ltd Recercat. Dipósit de la Recerca de Catalunya instname Dipòsit Digital de la UB Universidad de Barcelona Gastroenterology, 152(8), 1975-+. W.B. Saunders Gastroenterology, 152(8), 1975-1984. W B SAUNDERS CO-ELSEVIER INC |
| بيانات النشر: | W.B. Saunders, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Risk Stratification, Time Factors, Cholangitis, POPULATION-BASED COHORT, Ulcerative, Kaplan-Meier Estimate, Gastroenterology, Inflammatory bowel disease, Sclerosing, 0302 clinical medicine, Crohn Disease, Retrospective Studie, MED/12 - GASTROENTEROLOGIA, Risk Factors, Autoimmune Liver Disease, Multivariate Analysi, Crohn's disease, Cholestasis, Incidence, Hazard ratio, Immune-Mediated Liver Disease, Adult, Age Distribution, Australia, Chi-Square Distribution, Cholangitis, Sclerosing, Colitis, Ulcerative, Disease Progression, Europe, Female, Humans, Liver Transplantation, Middle Aged, Multivariate Analysis, North America, Phenotype, Prognosis, Proportional Hazards Models, Retrospective Studies, Risk Assessment, Sex Distribution, Young Adult, Colitis, Ulcerative colitis, Inflamació, CROHNS-DISEASE, 3. Good health, ULCERATIVE-COLITIS, Cholestasi, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Human, medicine.medical_specialty, Time Factor, Prognosi, Lower risk, Article, Primary sclerosing cholangitis, 03 medical and health sciences, Colitis ulcerosa, Internal medicine, medicine, GENOME-WIDE ASSOCIATION, PRIMARY BILIARY-CIRRHOSIS, Inflammation, Hepatology, business.industry, Proportional hazards model, Risk Factor, CLINICAL PRESENTATION, Retrospective cohort study, DOSE URSODEOXYCHOLIC ACID, NATURAL-HISTORY, medicine.disease, digestive system diseases, 3121 General medicine, internal medicine and other clinical medicine, RISK-FACTORS, Proportional Hazards Model, business, SINGLE-CENTER |
| الوصف: | BACKGROUND & AIMS: Primary sclerosing cholangitis (PSC) is an orphan hepatobiliary disorder associated with inflammatory bowel disease (IBD). We aimed to estimate the risk of disease progression based on distinct clinical phenotypes in a large international cohort of patients with PSC. METHODS: We performed a retrospective outcome analysis of patients diagnosed with PSC from 1980 through 2010 at 37 centers in Europe, North America, and Australia. For each patient, we collected data on sex, clinician-reported age at and date of PSC and IBD diagnoses, phenotypes of IBD and PSC, and date and indication of IBD-related surgeries. The primary and secondary endpoints were liver transplantation or death (LTD) and hepatopancreatobiliary malignancy, respectively. Cox proportional hazards models were applied to determine the effects of individual covariates on rates of clinical events, with time-to-event analysis ascertained through Kaplan-Meier estimates. RESULTS: Of the 7121 patients in the cohort, 2616 met the primary endpoint (median time to event of 14.5 years) and 721 developed hepatopancreatobiliary malignancy. The most common malignancy was cholangiocarcinoma (n = 594); patients of advanced age at diagnosis had an increased incidence compared with younger patients (incidence rate: 1.2 per 100 patient-years for patients younger than 20 years old, 6.0 per 100 patient-years for patients 21-30 years old, 9.0 per 100 patient-years for patients 31-40 years old, 14.0 per 100 patient-years for patients 4150 years old, 15.2 per 100 patient-years for patients 51-60 years old, and 21.0 per 100 patient-years for patients older than 60 years). Of all patients with PSC studied, 65.5% were men, 89.8% had classical or large-duct disease, and 70.0% developed IBD at some point. Assessing the development of IBD as a time-dependent covariate, Crohn's disease and no IBD (both vs ulcerative colitis) were associated with a lower risk of LTD (unadjusted hazard ratio [HR], 0.62; P |
| وصف الملف: | application/pdf |
| تدمد: | 1528-0012 0016-5085 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1873b2be5a096673b674a59e39b8c4cTest https://doi.org/10.1053/j.gastro.2017.02.038Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c1873b2be5a096673b674a59e39b8c4c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15280012 00165085 |
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