Utility of integrated HIV-1 DNA quantification in cure studies
| العنوان: | Utility of integrated HIV-1 DNA quantification in cure studies |
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| المؤلفون: | Alessandra Ruggiero, Linos Vandekerckhove, Ward De Spiegelaere, Sofie Rutsaert, William A. Paxton, Eva Malatinkova |
| المصدر: | Future Virology. 12:215-225 |
| بيانات النشر: | Future Medicine Ltd, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Dna load, Alu-gag PCR, Disease progression, Computational biology, Biology, Antiretroviral therapy, Peripheral blood, 03 medical and health sciences, 030104 developmental biology, HIV-1 reservoir, replication competency, Virology, Immunology, Viral persistence, Hiv 1 dna, integrated HIV-1 DNA |
| الوصف: | Numerous HIV-1 curative strategies have been proposed to eradicate the virus reservoir pool that remains integrated within target cells, despite successful antiretroviral therapy. To test the impact of such interventions on this reservoir, a universal marker of persistence is needed. Quantifying integrated HIV-1 DNA load has been proposed as a strong virological marker. In this paper, we provide a detailed description of the most commonly used assays to quantify integrated HIV-1 DNA and applications in relevant clinical studies produced over the last 20 years with a major focus on the recent literature. We discuss the potential for using this marker of virological persistence and the technical limitations that need to be addressed. |
| تدمد: | 1746-0808 1746-0794 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2814f15cb035fcb5f3d3c63eb0965f98Test https://doi.org/10.2217/fvl-2016-0130Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2814f15cb035fcb5f3d3c63eb0965f98 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17460808 17460794 |
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