التفاصيل البيبلوغرافية
| العنوان: |
Denosumab for the treatment of bone disease in solid tumors and multiple myeloma. |
| المؤلفون: |
Yee, Andrew J., Raje, Noopur S. |
| المصدر: |
Future Oncology; Feb2018, Vol. 14 Issue 3, p195-203, 9p |
| مستخلص: |
Bone is a common site for malignant involvement, either as a site of metastasis, especially in breast or prostate cancer, or as a defining characteristic of the disease, as in multiple myeloma. Bone disease is a major source of morbidity, and half of patients with bone involvement develop skeletal-related events such as pathological fractures or cord compression requiring surgery and/or radiation. Skeletal involvement also increases mortality, as pathologic fractures increase the risk of dying by 20-40%. Osteoclast inhibition with bisphosphonates such as zoledronic acid and recently denosumab has been a significant improvement for bone disease. This review will focus on denosumab in the treatment of bone metastases and highlight the recent findings in multiple myeloma. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
