Regulation of cancer germline antigen gene expression: implications for cancer immunotherapy
| العنوان: | Regulation of cancer germline antigen gene expression: implications for cancer immunotherapy |
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| المؤلفون: | Kunle Odunsi, Adam R. Karpf, S.N. Akers |
| المصدر: | Future Oncology. 6:717-732 |
| بيانات النشر: | Future Medicine Ltd, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Regulation of gene expression, Cancer Research, medicine.medical_treatment, Gene Expression, General Medicine, Immunotherapy, Biology, Article, Epigenesis, Genetic, Gene Expression Regulation, Neoplastic, Oncology, Antigen, Cancer immunotherapy, Antigens, Neoplasm, Neoplasms, Immunology, Cancer research, medicine, Humans, Cancer/testis antigens, Cancer vaccine, NY-ESO-1, Antigen Gene |
| الوصف: | Cancer germline (CG; also known as cancer-testis) antigen genes are normally expressed in germ cells and trophoblast tissues and are aberrantly expressed in a variety of human malignancies. CG antigen genes have high clinical relevance as they encode a class of immunogenic and highly selective tumor antigens. CG antigen-directed immunotherapy is undergoing clinical evaluation for the treatment of a number of solid tumor malignancies and has been demonstrated to be safe, provoke immune responses and be of therapeutic benefit. Achieving an improved understanding of the mechanisms of CG antigen gene regulation will facilitate the continued development of targeted therapeutic approaches against tumors expressing these antigens. Substantial evidence suggests epigenetic mechanisms, particularly DNA methylation, as a primary regulator of CG antigen gene expression in normal and cancer cells as well as in stem cells. The roles of sequence-specific transcription factors and signal transduction pathways in controlling CG antigen gene expression are less clear but are emerging. A combinatorial therapeutic approach involving epigenetic modulatory drugs and CG antigen immunotherapy is suggested based on these data and is being actively pursued. In this article, we review the mechanisms of CG antigen gene regulation and discuss the implications of these mechanisms for the development of cancer immunotherapy approaches targeting CG antigens. |
| تدمد: | 1744-8301 1479-6694 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e724238660ef5998a5fad3ede621e082Test https://doi.org/10.2217/fon.10.36Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e724238660ef5998a5fad3ede621e082 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17448301 14796694 |
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