Combination therapy in severe Acinetobacter baumannii infections: an update on the evidence to date
| العنوان: | Combination therapy in severe Acinetobacter baumannii infections: an update on the evidence to date |
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| المؤلفون: | Emanuele Durante-Mangoni, Raffaele Zarrilli, Riccardo Utili |
| المساهمون: | Durante Mangoni, E, Utili, R, Zarrilli, Raffaele |
| المصدر: | Future Microbiology. 9:773-789 |
| بيانات النشر: | Future Medicine Ltd, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Acinetobacter baumannii, Microbiology (medical), medicine.medical_specialty, Combination therapy, biology, business.industry, Critically ill, Antimicrobial, biology.organism_classification, Microbiology, Anti-Bacterial Agents, law.invention, Clinical trial, Antibiotic resistance, Randomized controlled trial, law, Drug Resistance, Multiple, Bacterial, Antibiotic therapy, Humans, Medicine, business, Intensive care medicine, Acinetobacter Infections, Randomized Controlled Trials as Topic |
| الوصف: | ABSTRACT: Acinetobacter baumannii is a drug-resistant Gram-negative pathogen increasingly causing hospital-acquired infections in critically ill patients. In this review, we summarize the current mechanisms of antimicrobial resistance in A. baumannii and describe in detail recent in vitro and in vivo experimental data on the activity of antimicrobial combinations against this microorganism. We then introduce the rationale for the use of combination antibiotic therapy in resistant A. baumannii infections. Finally, we present and critically discuss both uncontrolled clinical studies and the few randomized clinical trials of combination antimicrobial therapy for these infections, with a special focus on ongoing multinational trials and optimal approach to future research in this field. |
| تدمد: | 1746-0921 1746-0913 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ffc25d18e9cb6afd9bd80b77299db5Test https://doi.org/10.2217/fmb.14.34Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....81ffc25d18e9cb6afd9bd80b77299db5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17460921 17460913 |
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