التفاصيل البيبلوغرافية
| العنوان: |
Thyroid Autoantibodies Are Associated with a Reduced Prevalence of Frailty in Community-Dwelling Older Women |
| المؤلفون: |
Wang, George C., Talor, Monica V., Rose, Noel R., Cappola, Anne R., Chiou, Roger B., Weiss, Carlos, Walston, Jeremy D., Fried, Linda P., Caturegli, Patrizio |
| المصدر: |
ftcolumbiauniv |
| بيانات النشر: |
The Endocrine Society |
| سنة النشر: |
2010 |
| مصطلحات موضوعية: |
Autoantibodies, Thyroid gland, Older women, Endocrinology, Aging, Epidemiology, psy, demo |
| الوصف: |
Context: The contribution of autoimmunity to the multisystem dysregulation that characterizes the frailty syndrome in older adults is unknown. Objective: The aim of the study was to investigate the relationship between thyroid antibodies and frailty in older women. Design, Setting, and Participants: We conducted a cross-sectional study nested within the Women’s Health and Aging Studies I and II. Thyroglobulin antibodies (TgAbs), thyroid peroxidase antibodies (TPOAbs), and antinuclear antibodies were measured in the baseline sera of 641 community-dwelling older women. Main Outcome Measure: Frailty was defined using a validated five-component measure. Results: The prevalence of prefrailty and frailty was lower in TgAb-positive than negative older women (37.1 vs. 47.8% and 6.7 vs.11.9%, respectively; P = 0.01 and 0.03). The prevalence of prefrailty, but not frailty, was lower in TPOAb-positive than negative women (38.9 vs. 48.0% and 10.1 vs. 11.3%; P = 0.04 and 0.34). After adjustment for covariates including serum thyroid stimulation hormone concentration and thyroid medication usage in multinomial regression models, TgAb-positive older women had lower odds of prefrailty and frailty compared with TgAb-negative women (odds ratio 0.57 and 0.30; 95% confidence interval 0.34–0.98 and 0.10–0.85, respectively). Similarly, TPOAb-positive older women had lower odds of frailty compared with TPOAb-negative women (odds ratio 0.44; 95% confidence interval 0.20–0.96). These trends were not observed with antinuclear antibodies. Conclusion: Independent of thyroid function status, community-dwelling older women who are seropositive for TgAbs and TPOAbs are less likely to be frail than seronegative women. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
https://doi.org/10.7916/D8D50M8HTest |
| DOI: |
10.7916/D8D50M8H |
| الإتاحة: |
https://doi.org/10.7916/D8D50M8HTest |
| حقوق: |
undefined |
| رقم الانضمام: |
edsbas.78573CFB |
| قاعدة البيانات: |
BASE |
