Association Between Bipolar Disorder and Low Bone Mass: A Cross-Sectional Study With Newly Diagnosed, Drug-Naïve Patients
| العنوان: | Association Between Bipolar Disorder and Low Bone Mass: A Cross-Sectional Study With Newly Diagnosed, Drug-Naïve Patients |
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| المؤلفون: | Sujuan Li, Yan Qui, Ziwei Teng, Jindong Chen, Dongyu Kang, Hui Tang, Hui Xiang, Chujun Wu, Yuxi Tan, Lu Wang, Yanyi Yang, Bolun Wang, Haishan Wu |
| المصدر: | Frontiers in Psychiatry, Vol 11 (2020) Frontiers in Psychiatry |
| بيانات النشر: | Frontiers Media SA, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, lcsh:RC435-571, Cross-sectional study, Osteoporosis, Subgroup analysis, Overweight, 03 medical and health sciences, 0302 clinical medicine, lcsh:Psychiatry, Internal medicine, medicine, body mass index (BMI), Bipolar disorder, Original Research, drug-naïve, Psychiatry, bipolar disorder, Bone mineral, bone mineral density (BMD), business.industry, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Drug-naïve, gender difference, medicine.symptom, business, Body mass index, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | Background Medical comorbidities in people with mental disorders have recently gained more attention. People with bipolar disorder (BD) often have comorbid low bone mass, which is associated with increased fracture risk and related severe outcomes. However, few clinical studies on bone metabolism in BD patients are available. This study was designed to assess bone mineral density (BMD) and related influencing factors in a sample of newly diagnosed, drug-naive individuals with BD and age- and sex-matched healthy controls. Methods Sixty-one drug-naive individuals with BD (DSM-V) and 95 healthy volunteers had their lumbar spine (L1-L4) and left hip (Neck/Troch/Ward's) BMD determined by dual-energy X-ray absorptiometry. Besides, sociodemographic and clinical assessment were collected. Between-group comparisons and within subgroup analysis were performed. Results Drug-naive patients with BD had significantly lower BMD in comparison to healthy controls in multiple sites (L1, L3, Neck, Troch, Ward's, and total hip). On subgroup analysis, overweight individuals with BD had higher bone mass, while females presented reduced BMD. Binary logistic regression showed that low BMD in multiple regions was associated with BD diagnosis, body mass index (BMI), gender, and age. Conclusion Drug-naive individuals with BD have lower BMD when compared to an age- and gender-matched healthy control sample. Low BMI and female gender are factors associated with this outcome. The underlying pathological mechanisms of BD comorbid with osteoporosis should be further explored. Clinical trial registration www.chictr.org.cn, identifier ChiCTR190002137. |
| تدمد: | 1664-0640 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ae0954fd5f68ec0b4aca9dd4966c3eTest https://doi.org/10.3389/fpsyt.2020.00530Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....14ae0954fd5f68ec0b4aca9dd4966c3e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16640640 |
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