دورية أكاديمية
The role of the glucocorticoids in developing resilience to stress and addiction
| العنوان: | The role of the glucocorticoids in developing resilience to stress and addiction |
|---|---|
| المؤلفون: | Srinivasan, Subhashini, Shariff, Masroor, Bartlett, Selena |
| المصدر: | Frontiers in Psychiatry |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2013 |
| المجموعة: | Queensland University of Technology: QUT ePrints |
| مصطلحات موضوعية: | addiction, cholinergic, glucocorticoid, mifepristone, nicotinic acetylcholine receptors, orexin, resilience, stress |
| الوصف: | There is emerging evidence that individuals have the capacity to learn to be resilient by developing protective mechanisms that prevent them from the maladaptive effects of stress that can contribute to addiction.The emerging field of the neuroscience of resilience is beginning to uncover the circuits and molecules that protect against stress-related neuropsychiatric diseases, such as addiction. Glucocorticoids (GCs) are important regulators of basal and stress-related homeostasis in all higher organisms and influence a wide array of genes in almost every organ and tissue. GCs, therefore, are ideally situated to either promote or prevent adaptation to stress. In this review, we will focus on the role of GCs in the hypothalamic-pituitary adrenocortical axis and extra-hypothalamic regions in regulating basal and chronic stress responses. GCs interact with a large number of neurotransmitter and neuropeptide systems that are associated with the development of addiction. Additionally, the review will focus on the orexinergic and cholinergic pathways and highlight their role in stress and addiction. GCs play a key role in promoting the development of resilience or susceptibility and represent important pharmacotherapeutic targets that can reduce the impact of a maladapted stress system for the treatment of stress-induced addiction. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://eprints.qut.edu.au/67169/1/fpsyt-04-00068.pdfTest; Srinivasan, Subhashini, Shariff, Masroor, & Bartlett, Selena (2013) The role of the glucocorticoids in developing resilience to stress and addiction. Frontiers in Psychiatry, 4, pp. 1-11.; https://eprints.qut.edu.au/67169Test/; Faculty of Health; Institute of Health and Biomedical Innovation |
| الإتاحة: | https://doi.org/10.3389/fpsyt.2013.00068Test https://eprints.qut.edu.au/67169Test/ |
| حقوق: | free_to_read ; Consult author(s) regarding copyright matters ; This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au |
| رقم الانضمام: | edsbas.7B564047 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |