المؤلفون: Alexis Lheureux, Thibault Warlop, Charline Cambier, Baptiste Chemin, Gaëtan Stoquart, Christine Detrembleur, Thierry Lejeune

المصدر: Frontiers in Physiology, Vol 11 (2020)

مصطلحات موضوعية: gait disorders, rhythmic auditory stimulations, cueing, gait variability, long range autocorrelations, Parkinson’s disease, Physiology, QP1-981

الوصف: Parkinson’s Disease patients suffer from gait impairments such as reduced gait speed, shortened step length, and deterioration of the temporal organization of stride duration variability (i.e., breakdown in Long-Range Autocorrelations). The aim of this study was to compare the effects on Parkinson’s Disease patients’ gait of three Rhythmic Auditory Stimulations (RAS), each structured with a different rhythm variability (isochronous, random, and autocorrelated). Nine Parkinson’s Disease patients performed four walking conditions of 10–15 min each: Control Condition (CC), Isochronous RAS (IRAS), Random RAS (RRAS), and Autocorrelated RAS (ARAS). Accelerometers were used to assess gait speed, cadence, step length, temporal organization (i.e., Long-Range Autocorrelations computation), and magnitude (i.e., coefficient of variation) of stride duration variability on 512 gait cycles. Long-Range Autocorrelations were assessed using the evenly spaced averaged Detrended Fluctuation Analysis (α-DFA exponent). Spatiotemporal gait parameters and coefficient of variation were not modified by the RAS. Long-Range Autocorrelations were present in all patients during CC and ARAS although all RAS conditions altered them. The α-DFA exponents were significantly lower during IRAS and RRAS than during CC, exhibiting anti-correlations during IRAS in seven patients. α-DFA during ARAS was the closest to the α-DFA during CC and within normative data of healthy subjects. In conclusion, Isochronous RAS modify patients’ Long-Range Autocorrelations and the use of Autocorrelated RAS allows to maintain an acceptable level of Long-Range Autocorrelations for Parkinson’s Disease patients’ gait.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fphys.2020.601721/fullTest; https://doaj.org/toc/1664-042XTest

الوصول الحر: https://doaj.org/article/5cc924dbee224ea4b0004158877af08fTest

المؤلفون: Alexis Lheureux, Julien Lebleu, Caroline Frisque, Corentin Sion, Gaëtan Stoquart, Thibault Warlop, Christine Detrembleur, Thierry Lejeune

المصدر: Frontiers in Physiology, Vol 11 (2020)

مصطلحات موضوعية: Parkinson’s disease, gait disorders, gait assessment, virtual reality, gait variability, fractals, Physiology, QP1-981

الوصف: Effects of treadmill walking on Parkinson’s disease (PD) patients’ spatiotemporal gait parameters and stride duration variability, in terms of magnitude [coefficient of variation (CV)] and temporal organization [long range autocorrelations (LRA)], are known. Conversely, effects on PD gait of adding an optic flow during treadmill walking using a virtual reality headset, to get closer to an ecological walk, is unknown. This pilot study aimed to compare PD gait during three conditions: Overground Walking (OW), Treadmill Walking (TW), and immersive Virtual Reality on Treadmill Walking (iVRTW). Ten PD patients completed the three conditions at a comfortable speed. iVRTW consisted in walking at the same speed as TW while wearing a virtual reality headset reproducing an optic flow. Gait parameters assessed were: speed, step length, cadence, magnitude (CV) and temporal organization (evenly spaced averaged Detrended Fluctuation Analysis, α exponent) of stride duration variability. Motion sickness was assessed after TW and iVRTW using the Simulator Sickness Questionnaire (SSQ). Step length was greater (p = 0.008) and cadence lower (p = 0.009) during iVRTW compared to TW while CV was similar (p = 0.177). α exponent was similar during OW (0.77 ± 0.07) and iVRTW (0.76 ± 0.09) (p = 0.553). During TW, α exponent (0.85 ± 0.07) was higher than during OW (p = 0.039) and iVRTW (p = 0.016). SSQ was similar between TW and iVRTW (p = 0.809). iVRTW is tolerable, could optimize TW effects on spatiotemporal parameters while not increasing CV in PD. Furthermore, iVRTW could help to capture the natural LRA of PD gait in laboratory settings and could potentially be a challenging second step in PD gait rehabilitation.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/article/10.3389/fphys.2020.572063/fullTest; https://doaj.org/toc/1664-042XTest

الوصول الحر: https://doaj.org/article/41126f07ba9b44c1bbacd05d87886560Test

المؤلفون: Thibault Warlop, Christine Detrembleur, Gaëtan Stoquart, Thierry Lejeune, Anne Jeanjean

المصدر: Frontiers in Physiology, Vol 9 (2018)

مصطلحات موضوعية: Parkinson's disease, gait variability, treadmill, gait analysis, locomotion, rehabilitation, Physiology, QP1-981

الوصف: Variability raises considerable interest as a promising and sensitive marker of dysfunction in physiology, in particular in neurosciences. Both internally (e.g., pathology) and/or externally (e.g., environment) generated perturbations and the neuro-mechanical responses to them contribute to the fluctuating dynamics of locomotion. Defective internal gait control in Parkinson's disease (PD), resulting in typical timing gait disorders, is characterized by the breakdown of the temporal organization of stride duration variability. Influence of external cue on gait pattern could be detrimental or advantageous depending on situations (healthy or pathological gait pattern, respectively). As well as being an interesting rehabilitative approach in PD, treadmills are usually implemented in laboratory settings to perform instrumented gait analysis including gait variability assessment. However, possibly acting as an external pacemaker, treadmill could modulate the temporal organization of gait variability of PD patients which could invalidate any gait variability assessment. This study aimed to investigate the immediate influence of treadmill walking (TW) on the temporal organization of stride duration variability in PD and healthy population. Here, we analyzed the gait pattern of 20 PD patients and 15 healthy age-matched subjects walking on overground and on a motorized-treadmill (randomized order) at a self-selected speed. The temporal organization and regularity of time series of walking were assessed on 512 consecutive strides and assessed by the application of non-linear mathematical methods (i.e., the detrended fluctuation analysis and power spectral density; and sample entropy, for the temporal organization and regularity of gait variability, respectively). A more temporally organized and regular gait pattern seems to emerge from TW in PD while no influence was observed on healthy gait pattern. Treadmill could afford the necessary framework to regulate gait rhythmicity in PD. Overall, the results support the hypothesis of a greater dependence to regulatory inputs as an explanatory factor of treadmill influence observed in PD. Also, since treadmill misrepresents the gait as more healthy than it is, the present findings underline that gait analysis using treadmill devices should be cautiously considered in PD and especially for gait variability assessment in gait lab.

وصف الملف: electronic resource

العلاقة: http://journal.frontiersin.org/article/10.3389/fphys.2018.00068/fullTest; https://doaj.org/toc/1664-042XTest

الوصول الحر: https://doaj.org/article/acc5b8a26d204775b77e449bde1bc4b5Test

المؤلفون: Thierry Lejeune, Gaëtan Stoquart, Christine Detrembleur, Charline Cambier, Alexis Lheureux, Thibault Warlop, Baptiste Chemin

المساهمون: UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - SSS/IREC/NMSK - Neuro-musculo-skeletal Lab, UCL - (SLuc) Service de médecine physique et de réadaptation motrice, UCL - (SLuc) Service de neurologie

المصدر: Frontiers in Physiology, Vol 11 (2020)
Frontiers in Physiology, Vol. 11, p. 601721 [1-9] (2020)
Frontiers in Physiology

مصطلحات موضوعية: 030506 rehabilitation, medicine.medical_specialty, Parkinson's disease, Physiology, Gait disorders, STRIDE, Audiology, lcsh:Physiology, gait variability, 03 medical and health sciences, 0302 clinical medicine, Gait (human), Rhythm, Physiology (medical), medicine, long range autocorrelations, Rhythmic auditory stimulations, Long range autocorrelations, gait disorders, lcsh:QP1-981, business.industry, Autocorrelation, Gait variability, Brief Research Report, medicine.disease, Fractals, Cueing, Duration (music), fractals, rhythmic auditory stimulations, Parkinson’s disease, Detrended fluctuation analysis, 0305 other medical science, business, Cadence, human activities, 030217 neurology & neurosurgery, cueing

الوصف: Parkinson’s Disease patients suffer from gait impairments such as reduced gait speed, shortened step length, and deterioration of the temporal organization of stride duration variability (i.e., breakdown in Long-Range Autocorrelations). The aim of this study was to compare the effects on Parkinson’s Disease patients’ gait of three Rhythmic Auditory Stimulations (RAS), each structured with a different rhythm variability (isochronous, random, and autocorrelated). Nine Parkinson’s Disease patients performed four walking conditions of 10–15 min each: Control Condition (CC), Isochronous RAS (IRAS), Random RAS (RRAS), and Autocorrelated RAS (ARAS). Accelerometers were used to assess gait speed, cadence, step length, temporal organization (i.e., Long-Range Autocorrelations computation), and magnitude (i.e., coefficient of variation) of stride duration variability on 512 gait cycles. Long-Range Autocorrelations were assessed using the evenly spaced averaged Detrended Fluctuation Analysis (α-DFA exponent). Spatiotemporal gait parameters and coefficient of variation were not modified by the RAS. Long-Range Autocorrelations were present in all patients during CC and ARAS although all RAS conditions altered them. The α-DFA exponents were significantly lower during IRAS and RRAS than during CC, exhibiting anti-correlations during IRAS in seven patients. α-DFA during ARAS was the closest to the α-DFA during CC and within normative data of healthy subjects. In conclusion, Isochronous RAS modify patients’ Long-Range Autocorrelations and the use of Autocorrelated RAS allows to maintain an acceptable level of Long-Range Autocorrelations for Parkinson’s Disease patients’ gait.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e62479b317fa467bffcbefd62598e27Test
https://doi.org/10.3389/fphys.2020.601721Test