Polyacetylene From Dendropanax morbifera Alleviates Diet-Induced Obesity and Hepatic Steatosis by Activating AMPK Signaling Pathway
| العنوان: | Polyacetylene From Dendropanax morbifera Alleviates Diet-Induced Obesity and Hepatic Steatosis by Activating AMPK Signaling Pathway |
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| المؤلفون: | Myung-Ji Kang, Eun-Bin Kwon, Hyung Won Ryu, Seoghyun Lee, Jae-Won Lee, Doo-Young Kim, Mi Kyeong Lee, Sei-Ryang Oh, Hyun-Sun Lee, Su Ui Lee, Mun-Ock Kim |
| المصدر: | Frontiers in Pharmacology, Vol 9 (2018) Frontiers in Pharmacology |
| بيانات النشر: | Frontiers Media S.A., 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, AMPK, obesity, Dendropanax morbifera, Pharmacology, 03 medical and health sciences, chemistry.chemical_compound, Biosynthesis, Oral administration, medicine, Pharmacology (medical), triglyceride, Original Research, Triglyceride, hepatic steatosis, lcsh:RM1-950, medicine.disease, polyacetylene, Obesity, Oleic acid, 030104 developmental biology, lcsh:Therapeutics. Pharmacology, chemistry, Steatosis |
| الوصف: | The extract tea of Dendropanax morbifera is popular beverages in Korea, and their preventive and therapeutic roles in metabolic disorders have been reported. However, the molecular mechanism has not been studied despite the known efficacy of D. morbifera. Eleven fractions (fr.1–fr.11) were divided by MPLC to find the active compound. Among them, Fr.5 was superior to others in that the inhibitory efficacy of de novo triglyceride (TG) biosynthesis. NMR analysis revealed that Fr.5 is composed 98% or more (9Z,16S)-16-hydroxy-9,17-octadecadiene-12,14-diynoic acid (HOD). Treatment of HOD diminished oleic acid (OA)-induced TG accumulation in HepG2 hepatocytes and differentiation of 3T3-L1 preadipocytes by activating LKB1/AMPK. In addition, we determined the effect of the oral administration of the extract of D. morbifera on obesity and hepatic steatosis in high-fat diet (HFD)-induced obese mice. This study proved that D. morbifera containing HOD, the active substance, can show preventive or therapeutic efficacy on obesity and hepatic steatosis through the targeting LKB1/AMPK axis. |
| اللغة: | English |
| تدمد: | 1663-9812 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9344c97ccd6f842788eeef04f3512cfbTest https://www.frontiersin.org/article/10.3389/fphar.2018.00537/fullTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9344c97ccd6f842788eeef04f3512cfb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16639812 |
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