Solifenacin/Mirabegron Induces an Acute Compliance Increase in the Filling Phase of the Capacity-Reduced Urinary Bladder: A Pressure-Volume Analysis in Rats
| العنوان: | Solifenacin/Mirabegron Induces an Acute Compliance Increase in the Filling Phase of the Capacity-Reduced Urinary Bladder: A Pressure-Volume Analysis in Rats |
|---|---|
| المؤلفون: | Hsien-Yu Peng, Cheng-Yuan Lai, Ming-Chun Hsieh, Tzer-Bin Lin |
| المصدر: | Frontiers in Pharmacology, Vol 12 (2021) Frontiers in Pharmacology |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Bladder compliance, 030232 urology & nephrology, Urology, Urine, RM1-950, compliance, 03 medical and health sciences, 0302 clinical medicine, medicine, Pharmacology (medical), Original Research, Pharmacology, solifenacin, Solifenacin, Urinary bladder, medicine.diagnostic_test, business.industry, Cystometry, pressure-volume curve, urinary bladdder, mirabegron, Compliance (physiology), medicine.anatomical_structure, 030220 oncology & carcinogenesis, Pressure volume, Therapeutics. Pharmacology, Mirabegron, business, medicine.drug |
| الوصف: | Aims: Pressure in the bladder, which is a high compliance organ, is only slightly elevated to a considerable filling volume during storage. Although cystometry off-line offers mean compliance, no protocol is available for real-time assays of the dynamics of bladder compliance, and the potential impact of solifenacin and mirabegron on dynamic bladder compliance has not been established.Methods: Along with constantly infused cystometry, a pressure-volume analysis (PVA) was performed by plotting intra-vesical volume against pressure in Sprague-Dawley rats. The instant compliance was assayed as the slope of the trajectory, and the mean compliance (Cm) was determined by the slope of the line produced by regression of the data points at the end of the first, second, and third quarters of the filling phase.Results: Under a steady-state, the PVA trajectory moved clockwise which shaped coincident enclosed loops with stable compliance. Though administering to naïve animals solifenacin, but not mirabegron (both 1 × 10−5−1 × 10−1 mg/kg, i.a.) decreased the peak pressure, both of these reagents exhibited acute increments in the trajectory slope and Cm of the filling phase in a dose-dependent manner (ED50 = 1.4 × 10−4 and 2.2 × 10−5 mg/kg, respectively). Resembling urine frequency/urgency in OAB patients, the voiding frequency of a capacity-reduced bladder was increased in association with decreased compliance which was ameliorated by both acute solifenacin and mirabegron injections (both 1 × 10−1 mg/kg).Conclusion: In addition to their well-known anti-inotropic/relaxative effects, solifenacin, and mirabegron induce an acute increase in bladder compliance to ameliorate OAB-like syndromes. Together with time-domain cystometry, PVA offers a platform for investigating the physiology/pathophysiology/pharmacology of bladder compliance which is crucial for urine storage. |
| اللغة: | English |
| تدمد: | 1663-9812 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e924a96acb1a31eae69aa7382e7ef8Test https://www.frontiersin.org/articles/10.3389/fphar.2021.657959/fullTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....98e924a96acb1a31eae69aa7382e7ef8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16639812 |
|---|