Fibroblast Growth Factor 1 Ameliorates Diabetes-Induced Liver Injury by Reducing Cellular Stress and Restoring Autophagy
| العنوان: | Fibroblast Growth Factor 1 Ameliorates Diabetes-Induced Liver Injury by Reducing Cellular Stress and Restoring Autophagy |
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| المؤلفون: | Zeping Xu, Yanqing Wu, Fan Wang, Xiaofeng Li, Ping Wang, Yuying Li, Junnan Wu, Yiyang Li, Ting Jiang, Xindian Pan, Xie Zhang, Longteng Xie, Jian Xiao, Yanlong Liu |
| المصدر: | Frontiers in Pharmacology Frontiers in Pharmacology, Vol 11 (2020) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Type 2 diabetes, Fibroblast growth factor, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Fibrosis, Internal medicine, Diabetes mellitus, Medicine, oxidative stress, Pharmacology (medical), fibroblast growth factor 1, Original Research, Liver injury, Pharmacology, diabetes, business.industry, Endoplasmic reticulum, lcsh:RM1-950, FGF1, medicine.disease, 030104 developmental biology, Endocrinology, lcsh:Therapeutics. Pharmacology, 030220 oncology & carcinogenesis, endoplasmic reticulum stress, business, Oxidative stress, liver injury |
| الوصف: | s Background: Type 2 diabetes (T2D) is a metabolic dysfunction disease that causes several complications. Liver injury is one of these that severely affects patients with diabetes. Fibroblast growth factor 1 (FGF1) has glucose-lowering activity and plays a role in modulation of several liver injuries. Nevertheless, the effects and potential mechanisms of FGF1 against diabetes-induced liver injury are unknown. Methods: To further investigate the effect of FGF1 on diabetic liver injury, we divided db/db mice into two groups and intraperitoneally (i.p.) injected either with FGF1 at 0.5 mg/kg body weight or saline every other day for 4 weeks. Then body weights were measured. Serum and liver tissues were collected for biochemical and molecular analyses. Results: FGF1 significantly reduced blood glucose and ameliorated diabetes-induced liver steatosis, fibrosis and apoptosis. FGF1 also restored defective hepatic autophagy in db/db mice. Mechanistic investigations showed that diabetes markedly induced oxidative stress and endoplasmic reticulum stress and that FGF1 treatment significantly attenuated these effects. Conclusions: FGF1-associated glucose level reduction and amelioration of cellular stress are potential protective effects of FGF1 against diabetes-induced liver injury. Key words: Fibroblast growth factor 1 (FGF1); Diabetes; Liver injury; Oxidative stress; Endoplasmic reticulum (ER) stress |
| تدمد: | 1663-9812 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad676b972f8de60eb576e0adf26fa82Test https://pubmed.ncbi.nlm.nih.gov/32194395Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fad676b972f8de60eb576e0adf26fa82 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16639812 |
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